A broad-spectrum antiviral agent
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Labeled Version(s)
31494Umifenovir-d6 (hydrochloride)
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Umifenovir (hydrochloride)

Item No. 16933

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-[(phenylthio)methyl]-1H-indole-3-carboxylic acid, ethyl ester, monohydrochloride
CAS Number
131707-23-8
Synonyms
  • Arbidol
Molecular Formula
C22H25BrN2O3S • HCl
Formula Weight
513.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:8): 0.1 mg/mlDMSO: 15 mg/mlEthanol: 10 mg/ml
λmax
225, 255, 315 nm
SMILES
CN1C(CSC2=CC=CC=C2)=C(C(OCC)=O)C3=C(CN(C)C)C(O)=C(Br)C=C31.Cl
InChi Code
InChI=1S/C22H25BrN2O3S.ClH/c1-5-28-22(27)20-18(13-29-14-9-7-6-8-10-14)25(4)17-11-16(23)21(26)15(19(17)20)12-24(2)3;/h6-11,26H,5,12-13H2,1-4H3;1H
InChi Key
OMZHXQXQJGCSKN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Cayman Chemical
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    Product Description

    Umifenovir is a broad-spectrum antiviral agent.1 It inhibits the replication of H5N1 influenza (IC50 = 30 µg/ml) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro (IC50 = 3.537 µM).1,2 Umifenovir inhibits entry of hepatitis C virus (HCV) pseudoparticles in Huh7 cells (IC50 = 6 µg/ml) and inhibits Zika virus protein synthesis in Vero cells.1,3 In vivo, umifenovir (45 mg/kg) reduces the formation of influenza-induced lung lesions in ferrets.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Boriskin, Y.S., Leneva, I.A., Pécheur, E.I., et al. Arbidol: A broad-spectrum antiviral compound that blocks viral fusion. Curr. Med. Chem. 15(10), 997-1005 (2008).

    2. Pizzorno, A., Padey, B., Dubois, J., et al. In vitro evaluation of antiviral activity of single and combined repurposable drugs against SARS-CoV-2. Antiviral Res. 181, 104878 (2020).

    3. Fink, S.L., Vojtech, L., Wagoner, J., et al. The antiviral drug arbidol inhibits Zika virus. Sci. Rep. 8(1), 8989 (2018).

    4. Wang, Y., Ding, Y., Yang, C., et al. Inhibition of the infectivity and inflammatory response of influenza virus by Arbidol hydrochloride in vitro and in vivo (mice and ferret). Biomed. Pharmacother. 91, 393-401 (2017).