An NHE-1 inhibitor
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Cariporide

Item No. 16935

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)-benzamide
CAS Number
159138-80-4
Synonyms
  • HOE 642
Molecular Formula
C12H17N3O3S
Formula Weight
283.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 20 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/mlEthanol: 10 mg/ml
λmax
210, 260 nm
SMILES
CS(C1=C(C(C)C)C=CC(C(NC(N)=N)=O)=C1)(=O)=O
InChi Code
InChI=1S/C12H17N3O3S/c1-7(2)9-5-4-8(11(16)15-12(13)14)6-10(9)19(3,17)18/h4-7H,1-3H3,(H4,13,14,15,16)
InChi Key
IWXNYAIICFKCTM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $69

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    10 mg

    $120

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    50 mg

    $525

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    100 mg

    $918

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    Product Description

    Cariporide is an inhibitor of sodium-hydrogen exchanger 1 (NHE-1; IC50 = 0.56 µM in an intracellular pH recovery assay).1 It is selective for NHE-1 over NHE-2 (IC50 = 28 µM in an intracellular pH recovery assay). Cariporide inhibits sodium propionate-induced swelling of isolated human platelets (IC50 = 0.023 µM). It reduces the myocardial infarct size as a percentage of the area at risk in a rabbit model of ischemia-reperfusion injury induced by coronary artery occlusion when administered at a dose of 1 mg/kg. Cariporide (1 mg/kg) decreases ventricular tachycardia duration in a rat model of coronary artery ligation and reperfusion-induced arrhythmia.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tracey, W.R., Allen, M.C., Frazier, D.E., et al. Zoniporide: A potent and selective inhibitor of the human sodium-hydrogen exchanger isoform 1 (NHE-1). Cardiovasc. Drug Rev. 21(1), 17-32 (2003).

    2. Xue, Y.X., Aye, N.N., and Hashimoto, K. Antiarrhythmic effects of HOE642, a novel Na+-H+ exchange inhibitor, on ventricular arrhythmias in animal hearts. Eur. J. Pharmacol. 317(2-3), 309-316 (1996).