A modulator of diverse GPCRs
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Product Type

Small Molecule Modulators
Receptor Pharmacology

Research Area

Neuroscience

SCH 202676 (hydrobromide)

Item No. 16945

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2,3-diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)-methanamine, monohydrobromide
CAS Number
265980-25-4
Molecular Formula
C15H13N3S • HBr
Formula Weight
348.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 10 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
λmax
205, 275 nm
SMILES
C/N=C1SN(C2=CC=CC=C2)C(C3=CC=CC=C3)=N\1.Br
InChi Code
InChI=1S/C15H13N3S.BrH/c1-16-15-17-14(12-8-4-2-5-9-12)18(19-15)13-10-6-3-7-11-13;/h2-11H,1H3;1H/b16-15-;
InChi Key
YJYGOWVFDGULLL-YFKNTREVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $69

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    10 mg

    $127

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    25 mg

    $297

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    50 mg

    $525

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    Product Description

    SCH 202676 is a reversible inhibitor of both agonist and antagonist binding to diverse G protein-coupled receptors (GPCRs).1 It blocks the binding of radiolabeled ligands to human opioid, adrenergic, muscarinic, dopaminergic, adenosine, and purinergic receptors.1,2,3 It displays IC50 values of 0.1 to 1.8 µM for modulating ligand binding.1,2 SCH 202676 may modulate GPCRs via thiol modification.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fawzi, A.B., Macdonald, D., Benbow, L.L., et al. SCH-202676: An allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors. Mol. Pharmacol. 59(1), 30-37 (2001).

    2. Gao, Z.G., Kim, S.K., Ijzerman, A.P., et al. Allosteric modulation of the adenosine family of receptors. Mini Rev. Med. Chem. 5(6), 545-553 (2005).

    3. Lanzafame, A., and Christopoulos, A. Investigation of the interaction of a putative allosteric modulator, N-(2,3-diphenyl-1,2,4-thiadiazole-5-(2H)-ylidene) methanamine hydrobromide (SCH-202676), with M1 muscarinic acetylcholine receptors. J. Pharmacol. Exp. Ther. 308(3), 830-837 (2004).

    4. Lewandowicz, A.M., Vepsäläinen, J., and Laitinen, J.T. The 'allosteric modulator' SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms. Br. J. Pharmacol. 147(4), 422-429 (2006).