An inhibitor of HIF-2α PAS-B domain heterodimerization

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Product Categories

Product Type

Biochemicals

Research Area

Cancer

Transcription Factors

HIF-2α Antagonist 2

Name: HIF-2α Antagonist 2
Brand: -

Item No. 16971

HIF-2α Antagonist 2 (Hypoxia-Inducible Factor-2α Antagonist 2, CAS Number: 1422955-31-4)

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)

Technical Information

Formal Name

N-(3-chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine

CAS Number

1422955-31-4

Synonyms

Hypoxia-Inducible Factor-2α Antagonist 2

Molecular Formula

C₁₂H₆ClFN₄O₃

Formula Weight

308.7

Purity

≥98%

Formulation (Request formulation change)

A solid

Solubility(Learn about Variance in Solubility)

DMSO: 30 mg/ml

SMILES

ClC1=CC(F)=CC(NC2=C([N+]([O-])=O)C3=NON=C3C=C2)=C1

InChi Code

InChI=1S/C12H6ClFN4O3/c13-6-3-7(14)5-8(4-6)15-10-2-1-9-11(17-21-16-9)12(10)18(19)20/h1-5,15H

InChi Key

CDQUJZKBRAFWNG-UHFFFAOYSA-N

Shipping & Storage Information

Storage

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

Certificates of Analysis & Batch Specific Data

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1 mg

$42

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5 mg

$94

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Product Description

HIF-2α antagonist 2 is an inhibitor of hypoxia-inducible factor-2α (HIF-2α) PAS-B domain heterodimerization.¹ It binds to the HIF-2α PAS-B domain (K_d = 81 nM) to inhibit heterodimerization with the aryl hydrocarbon receptor nuclear translocator (ARNT) PAS-B domain in cell-free assays when used at concentrations ranging from 0.1 to 100 µM. HIF-2α antagonist 2 (0.1-30 µM) decreases expression of the HIF-2α target gene VEGFA in 786-O renal carcinoma cells.

WARNING This product is not for human or veterinary use.

References & Product Citations

Product Description References

1. Scheuermann, T.H., Li, Q., Ma, H.-W., et al. Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nat. Chem. Biol. 9(4), 271-276 (2013).

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