An inhibitor of hedgehog acyltransferase
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RU-SKI 43 (hydrochloride)

Item No. 16972

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[6,7-dihydro-4-[(3-methylphenoxy)methyl]thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]-ethanone, monohydrochloride
CAS Number
1782573-67-4
Molecular Formula
C22H30N2O2S • HCl
Formula Weight
423.0
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
λmax
272 nm
SMILES
CC1=CC=CC(OCC2C(C=CS3)=C3CCN2C(CNCC(C)CC)=O)=C1.Cl
InChi Code
InChI=1S/C22H30N2O2S.ClH/c1-4-16(2)13-23-14-22(25)24-10-8-21-19(9-11-27-21)20(24)15-26-18-7-5-6-17(3)12-18;/h5-7,9,11-12,16,20,23H,4,8,10,13-15H2,1-3H3;1H
InChi Key
JBBKLHJLHRGJSQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $41

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    5 mg

    $157

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    10 mg

    $235

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    Cayman Chemical
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    Product Description

    RU-SKI 43 is an inhibitor of Hhat (IC50 = 0.85 µM).1 It blocks palmitoylation of Shh without affecting palmitoylation of H-Ras or Fyn, myristoylation of c-Src, or acylation of Wnt3a.1 RU-SKI 43 is cell-permeable and inhibits both autocrine and paracrine Shh-induced activation of Gli-mediated transcription.1 In pancreatic cancer cells, RU-SKI 43 reduces both Gli1 activation and proliferation.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Petrova, E., Rios-Esteves, J., Ourfelli, O., et al. Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling. Nat. Chem. Biol. 9(4), 247-249 (2013).

    2. Petrova, E., Matevossian, A., and Resh, M.D. Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma. Oncogene 34, 263-268 (2015).