A specialized pro-resolving mediator
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MCTR2

Item No. 17008

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
S-[(1R,2E,4E,6Z,9Z)-12-carboxy-1-[(1S,3Z,6Z)-1-hydroxy-3,6-nonadien-1-yl]-2,4,6,9-dodecatetraen-1-yl]-L-cysteinyl-glycine
CAS Number
1784701-62-7
Synonyms
  • 13-cysteinylglycinyl-14-hydroxy Docosahexaenoic Acid
  • Maresin Conjugates in Tissue Regeneration 2
  • Maresin Sulfido Conjugate 2
Molecular Formula
C27H40N2O6S
Formula Weight
520.7
Purity
≥97%
Formulation (Request formulation change)
A 100 µg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 1 mg/mlEthanol:Water (95:5): 2 mg/mlPBS (pH 7.2): 100 µg/ml
λmax
282 nm
SMILES
O[C@@H](C/C=C\C/C=C\CC)[C@H](SC[C@H](N)C(NCC(O)=O)=O)/C=C/C=C/C=C\C/C=C\CCC(O)=O
InChi Code
InChI=1S/C27H40N2O6S/c1-2-3-4-5-11-14-17-23(30)24(36-21-22(28)27(35)29-20-26(33)34)18-15-12-9-7-6-8-10-13-16-19-25(31)32/h3-4,6-7,9-15,18,22-24,30H,2,5,8,16-17,19-21,28H2,1H3,(H,29,35)(H,31,32)(H,33,34)/b4-3-,7-6-,12-9+,13-10-,14-11-,18-15+/t22-,23-,24+/m0/s1
InChi Key
CPBQPRBQBDLLLA-VZUSUAOUSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    10 µg

    $169

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    25 µg

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    50 µg

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    100 µg

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    Product Description

    Maresin conjugates in tissue regeneration 2 (MCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid (DHA; Item No. 90310) in macrophages at the site of inflammation.1,2 DHA is oxidized to maresin 1 (MaR1; Item No. 10878), which is converted to MCTR1 (Item No. 17007) by glutathione S-transferase Mu 4 or leukotriene C4 synthase then to MCTR2 by γ-glutamyl transferase.3 MCTR2 accelerates tissue regeneration in planaria (1 and 100 nM).2 Pretreatment with MCTR2 prior to E. coli administration reduces neutrophil infiltration, shortens the inflammatory resolution period, and increases phagocytosis of E. coli by macrophages.2 When administered at a dose of 100 ng 12h post E. coli infection in a mouse model of peritonitis, MCTR2 selectively reduced the amount of the eicosanoids PGD2 (Item No. 12010) and PGF2α (Item No. 16010) in the exudate.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Serhan, C.N. Novel pro-resolving lipid mediators in inflammation are leads for resolution physiology. Nature 510(7503), 92-101 (2014).

    2. Dalli, K.J., Sanger, J.M., Rodriguez, A.R., et al. Identification and actions of a novel third maresin conjugate in tissue regeneration: MCTR3. PLoS One 11(2), e0149319 (2016).

    3. Dalli, J., Vlasakov, I., Riley, I.R., et al. Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages. Proc. Natl. Acad. Sci. USA 113(43), 12232-12237 (2016).