The first stable intermediate in the COX pathway
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Active Metabolite(s)
17020Prostaglandin H2
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Prostaglandin G2

Item No. 17010

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9α,11α-epidioxy-15S-hydroperoxy-prosta-5Z,13E-dien-1-oic acid
CAS Number
51982-36-6
Synonyms
  • PGG2
Molecular Formula
C20H32O6
Formula Weight
368.5
Purity
≥95%
Formulation (Request formulation change)
A 100 µg/ml solution in acetone
Solubility(Learn about Variance in Solubility)
Ethanol: >100 mg/mlPBS (pH 7.2): >2 mg/ml
SMILES
CCCCC[C@@H](OO)/C=C/[C@H]1[C@@H]2OO[C@@H](C2)[C@H]1C/C=C\CCCC(O)=O
InChi Code
InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15?,16-,17+,18-,19+/m0/s1
InChi Key
SGUKUZOVHSFKPH-CEJHIBGISA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    25 µg

    $98

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    50 µg

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    100 µg

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    500 µg

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    Product Description

    Prostaglandin G2 (PGG2) is the first intermediate in the COX pathway which is stable enough to be isolated and characterized.1 It is the C-15 hydroperoxide of PGH2. Under normal conditions, PGG2 is quickly metabolized by the peroxidase activity intrinsic to both COX-1 and -2 to give PGH2, which serves as the key precursor to the 2-series PGs and thromboxanes.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hamberg, M., Svensson, J., and Samuelsson, B. Prostaglandin endoperoxides. A new concept concerning the mode of action and release of prostaglandins. Proc. Natl. Acad. Sci. USA 71(10), 3824-3828 (1974).

    2. Kulmacz, R.J. Prostaglandin G2 levels during reaction of prostaglandin H synthase with arachidonic acid. Prostaglandins 34(2), 225-240 (1987).

    Product Citations

    Sorgi, C.A., Peti, A.P.F., Petta, T., et al. Comprehensive high-resolution multiple-reaction monitoring mass spectrometry for targeted eicosanoid assays. Sci. Data 5, 180167 (2018).