An Analytical Reference Standard
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Tenocyclidine (hydrochloride)

Item No. 17014

Restricted Product (Schedule I)
Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • TCP
Technical Information
Formal Name
1-[1-(2-thienyl)cyclohexyl]-piperidine, monohydrochloride
CAS Number
1867-65-8
Molecular Formula
C15H23NS • HCl
Formula Weight
285.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 2 mg/mlEthanol: 2 mg/mlMethanol: 1 mg/ml
λmax
235 nm
SMILES
N1(CCCCC1)C2(C3=CC=CS3)CCCCC2.Cl
InChi Code
InChI=1S/C15H23NS.ClH/c1-3-9-15(10-4-1,14-8-7-13-17-14)16-11-5-2-6-12-16;/h7-8,13H,1-6,9-12H2;1H
InChi Key
IIPLEZRBGQCZMF-UHFFFAOYSA-N
Regulatory Information
DEA Schedule
I
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $69

    Add

    5 mg

    $297

    Add

    10 mg

    $525

    Add
    Cayman Chemical
    Cayman Spectral Library

    Our free, searchable, GC-MS spectral database contains 70eV EI mass spectral data of 2,000+ of Cayman’s forensic drug standards.

    DOWNLOAD THE DATABASE
    Product Description

    Tenocyclidine (TCP), known more formally as N-[1-(2-thienyl)cyclohexyl] piperidine, is an analog of phencyclidine (PCP) in which the phenyl substituent is replaced with a thiophene group. TCP is a potent antagonist of the NMDA receptor-gated ion channel (Kd = 9 nM).1 TCP blocks NMDA-activated excitatory postsynaptic potential in brain more potently than PCP.2 PCP and many analogs, including TCP, block the uptake and enhance the release of dopamine both in vitro and in vivo.3 TCP is regulated as a Schedule I compound in the United States. This product is intended for forensic and research applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yeh, G.C., Bonhaus, D.W., Nadler, J.V., et al. N-methyl-D-aspartate receptor plasticity in kindling: Quantitative and qualitative alterations in the N-methyl-ᴅ-aspartate receptor-channel complex. Proc. Natl. Acad. Sci. USA 86(20), 8157-8160 (1989).

    2. Bartschat, D.K., and Blaustein, M.P. Phencyclidine in low doses selectively blocks a presynaptic voltage-regulated potassium channel in rat brain. Proc. Natl. Acad. Sci. USA 83(1), 189-192 (1986).

    3. Chaudieu, I., Vignon, J., Chicheportiche, M., et al. Role of the aromatic group in the inhibition of phencyclidine binding and dopamine uptake by PCP analogs. Pharmacol. Biochem. Behav. 32(3), 699-705 (1989).