The precursor to all 1-series prostaglandins and thromboxanes
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Prostaglandin H1

Item No. 17015

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9α,11α-epidioxy-15S-hydroxy-prost-13E-en-1-oic acid
CAS Number
52589-22-7
Synonyms
  • PGH1
  • PGR1
  • Prostaglandin R1
Molecular Formula
C20H34O5
Formula Weight
354.5
Purity
≥95%
Formulation
A 100 µg/ml solution in acetone
Solubility(Learn about Variance in Solubility)
Ethanol: >100 mg/mlPBS pH 7.2: >2 mg/ml
SMILES
CCCCC[C@H](O)/C=C/[C@H]1[C@@H]2OO[C@@H](C2)[C@H]1CCCCCCC(O)=O
InChi Code
InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h12-13,15-19,21H,2-11,14H2,1H3,(H,22,23)/b13-12+/t15-,16-,17+,18-,19+/m0/s1
InChi Key
NTAYABHEVAQSJS-PUCCXBQTSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    Product Description

    Prostaglandin H1 (PGH1) is the unstable precursor to all 1-series PGs and thromboxanes.1,2,3 It is produced from dihomo-γ-linolenic acid (DGLA; Item No. 90230) by COX-1 and COX-2. 4,2 PGH1 is an agonist of the PGD2 receptor CRTH2.5 It increases intracellular calcium levels in HEK293 cells expressing CRTH2 when used at a concentration of 3 µM and induces CRTH2 internalization at 1 µM, an effect that can be blocked by the CRTH2 antagonist TM30089 (CAY10471; Item No. 10006735). PGH1 is also a suicide inhibitor of platelet thromboxane synthase (Ki = 28 µM).6

    WARNING This product is not for human or veterinary use.