A potent allosteric inhibitor of PRMT3
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SGC707

Item No. 17017

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)Epigenetic Chemical Probe Guide (PDF)
Technical Information
Formal Name
N-6-isoquinolinyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]-urea
CAS Number
1687736-54-4
Molecular Formula
C16H18N4O2
Formula Weight
298.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 2 mg/mlEthanol: 5 mg/ml
λmax
248, 294 nm
SMILES
O=C(NCC(N1CCCC1)=O)NC2=CC3=CC=NC=C3C=C2
InChi Code
InChI=1S/C16H18N4O2/c21-15(20-7-1-2-8-20)11-18-16(22)19-14-4-3-13-10-17-6-5-12(13)9-14/h3-6,9-10H,1-2,7-8,11H2,(H2,18,19,22)
InChi Key
DMIDPTCQPIJYFE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    10 mg

    $186

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    25 mg

    $420

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    50 mg

    $736

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    Product Description

    SGC707 is a potent allosteric inhibitor of PRMT3 (IC50 = 50 nM) with >100-fold selectivity over other methyltransferases and other non-epigenetic targets. Developed by the Structural Genomics Consortium (SGC), SGC707 avidly binds PRMT3 (Kd = 50 nM by isothermal titration calorimetry) and inhibits the methylation of histones in cells with an IC50 value below 1 µM.

    WARNING This product is not for human or veterinary use.