A FFAR4 agonist
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

TUG-891

Item No. 17035

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]-benzenepropanoic acid
CAS Number
1374516-07-0
Molecular Formula
C23H21FO3
Formula Weight
364.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:5): 0.1 mg/mlEthanol: 1 mg/ml
SMILES
CC1=CC=C(C2=CC=C(F)C=C2COC3=CC=C(CCC(O)=O)C=C3)C=C1
InChi Code
InChI=1S/C23H21FO3/c1-16-2-7-18(8-3-16)22-12-9-20(24)14-19(22)15-27-21-10-4-17(5-11-21)6-13-23(25)26/h2-5,7-12,14H,6,13,15H2,1H3,(H,25,26)
InChi Key
LPGBXHWIQNZEJB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $38

    Add

    5 mg

    $110

    Add

    10 mg

    $183

    Add

    25 mg

    $399

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    TUG-891 is an agonist of free fatty acid receptor 4 (FFAR4/GPR120; EC50s = 0.0436 and 0.0169 µM for the human and mouse receptors, respectively).1 It is selective for FFAR4 over FFAR1/GPR40 (EC50 = 64.5 µM for the human receptor) and is inactive against FFAR2/GPR43 and FFAR3/GPR41. TUG-891 (1 µM) inhibits lysophosphatidic acid- or EGF-induced proliferation and migration of DU145 and PC3 prostate cancer cells.2 It stimulates glucagon-like peptide 1 (GLP-1) release in STC-1 enteroendrocrine cells and glucose uptake in 3T3-L1 adipocytes, as well as inhibits LPS-induced TNF-α release in RAW 264.7 macrophages when used at a concentration of 10 µM.3 TUG-891 (20 mg/kg) reduces sleep fragmentation-induced increases in food consumption and epididymal fat mass in mice.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shimpukade, B., Hudson, B.D., Hovgaard, C.K., et al. Discovery of a potent and selective GPR120 agonist. J. Med. Chem. 55(9), 4511-4515 (2012).

    2. Liu, Z., Hopkins, M.M., Zhang, Z., et al. Omega-3 fatty acids and other FFA4 agonists inhibit growth factor signaling in human prostate cancer cells. J. Pharmacol. Exp. Ther. 352(2), 380-394 (2015).

    3. Hudson, B.D., Shimpukade, B., Mackenzie, A.E., et al. The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism. Mol. Pharmacol. 84(5), 710-725 (2013).

    4. Gozal, D., Qiao, Z., Almendros, I., et al. Treatment with TUG891, a free fatty acid receptor 4 agonist, restores adipose tissue metabolic dysfunction following chronic sleep fragmentation in mice. Int. J. Obes. (Lond.) 40(7), 1143-1149 (2016).