A FAHFA with anti-diabetic potential
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Active Metabolite(s)
180169-hydroxy Stearic Acid
Labeled Version(s)
177259-PAHSA 13C4 173979-PAHSA-d31 177249-PAHSA-d4
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9-PAHSA

Item No. 17037

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-[(1-oxohexadecyl)oxy]-octadecanoic acid
CAS Number
1481636-31-0
Molecular Formula
C34H66O4
Formula Weight
538.9
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 15 mg/mlEthanol: 20 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
SMILES
OC(CCCCCCCC(OC(CCCCCCCCCCCCCCC)=O)CCCCCCCCC)=O
InChi Code
InChI=1S/C34H66O4/c1-3-5-7-9-11-12-13-14-15-16-18-23-27-31-34(37)38-32(28-24-20-17-10-8-6-4-2)29-25-21-19-22-26-30-33(35)36/h32H,3-31H2,1-2H3,(H,35,36)
InChi Key
MHQWHZLXDBVXML-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $69

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    5 mg

    $297

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    10 mg

    $525

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    Product Description

    9-PAHSA is a FAHFA in which palmitic acid is esterified to 9-hydroxy stearic acid. PAHSAs are the most abundant forms of FAHFA in serum as well as white and brown adipose tissues of glucose tolerant AG4OX mice, which overexpress Glut4 specifically in adipose tissue.1 9-PAHSA is the predominant isomer of PAHSA in wild type and AG4OX mice.1 It is found in humans and is reduced in the serum and adipose tissues of insulin-resistant humans.1 9-PAHSA improves glucose tolerance, stimulates insulin secretion, and has anti-inflammatory effects in mice.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yore, M.M., Syed, I., Moraes-Vieira, P.M., et al. Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. Cell 159(2), 318-332 (2014).

    Product Citations

    Aryal, P., Syed, I., Lee, J., et al. Distinct biological activities of isomers from several families of branched fatty acid esters of hydroxy fatty acids (FAHFAs). J. Lipid Res. 62, 100108 (2021).