A macrolide antibiotic
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Tildipirosin

Item No. 17089

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
20-deoxo-23-deoxy-5-O-[3,6-dideoxy-3-(dimethylamino)-β-D-glucopyranosyl]-20,23-di-1-piperidinyl-tylonolide
CAS Number
328898-40-4
Molecular Formula
C41H71N3O8
Formula Weight
734.0
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:2): 0.33 mg/ml
λmax
286 nm
SMILES
CC1=C/[C@@H]([C@H](OC(C[C@H]([C@@H]([C@H]([C@H](C[C@H](C(/C=C/1)=O)C)CCN2CCCCC2)O[C@@]3(O[C@@H]([C@H]([C@@H]([C@H]3O)N(C)C)O)C)[H])C)O)=O)CC)CN4CCCCC4
InChi Code
InChI=1S/C41H71N3O8/c1-8-35-32(26-44-20-13-10-14-21-44)23-27(2)15-16-33(45)28(3)24-31(17-22-43-18-11-9-12-19-43)40(29(4)34(46)25-36(47)51-35)52-41-39(49)37(42(6)7)38(48)30(5)50-41/h15-16,23,28-32,34-35,37-41,46,48-49H,8-14,17-22,24-26H2,1-7H3/b16-15+
InChi Key
HNDXPZPJZGTJLJ-UEJFNEDBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Tildipirosin is a 16-membered macrolide used as an antibiotic in veterinary medicine. Like other macrolides, it inhibits protein synthesis in bacteria and blocks the production of biofilms.1,2 Tildipirosin is particularly effective against Gram-negative pathogens (MIC = 0.25-1 µg/ml against P. multocida and M. haemolytica).1,3 It is commonly used against respiratory infections in swine and cattle.1,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Andersen, N.M., Poehlsgaard, J., Warrass, R., et al. Inhibition of protein synthesis on the ribosome by tildipirosin compared with other veterinary macrolides. Antimicrob. Agents Chemother. 56(11), 6033-6036 (2012).

    2. Rademacher, J., and Welte, T. Bronchiectasis-diagnosis and treatment. Dtsch. Arztebl. Int. 108(48), 809-815 (2011).

    3. Michael, G.B., Eidam, C., Kadlec, K., et al. Increased MICs of gamithromycin and tildipirosin in the presence of the genes erm(42) and msr(E)-mph(E) for bovine Pasteurella multocida and Mannheimia haemolytica. J. Antimicrob. Chemother. 67(6), 1555-1557 (2012).