A potent inhibitor of NCOAT (O-GlcNAcase)
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(Z)-PUGNAc

Item No. 17151

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1Z)-δ-lactone-2-(acetylamino)-2-deoxy-N-[[(phenylamino)carbonyl]oxy]-D-gluconimidic acid
CAS Number
132489-69-1
Molecular Formula
C15H19N3O7
Formula Weight
353.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 1 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
236 nm
SMILES
O=C(C)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O/C1=N\OC(NC2=CC=CC=C2)=O
InChi Code
InChI=1S/C15H19N3O7/c1-8(20)16-11-13(22)12(21)10(7-19)24-14(11)18-25-15(23)17-9-5-3-2-4-6-9/h2-6,10-13,19,21-22H,7H2,1H3,(H,16,20)(H,17,23)/b18-14-/t10-,11-,12-,13-/m1/s1
InChi Key
PBLNJFVQMUMOJY-JXZOILRNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $153

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    10 mg

    $236

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    Product Description

    (Z)-PUGNAc is a stereoisomer of PUGNAc that is a more potent inhibitor of NCOAT than the (E) isomer, both in vitro and in cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Perreira, M., Kim, E.J., Thomas, C.J., et al. Inhibition of O-GlcNAcase by PUGNAc is dependent upon the oxime stereochemistry. Bioorg. Med. Chem. 14(3), 837-846 (2006).