A macrocyclic lactone endectocide
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Labeled Version(s)
28766Moxidectin-d3
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Moxidectin

Item No. 17165

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(6R,23E,25S)-5-O-demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-buten-1-yl]-6,28-epoxy-23-(methoxyimino)-milbemycin B
CAS Number
113507-06-5
Synonyms
  • CL-301423
Molecular Formula
C37H53NO8
Formula Weight
639.8
Purity
≥90%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 25 mg/ml
λmax
244 nm
SMILES
O=C([C@@]1([H])[C@@]2(O)[C@@]3([H])[C@H](O)C(C)=C1)O[C@@]4([H])C[C@](C/C=C(C)/C[C@@H](C)/C=C/C=C2\CO3)([H])O[C@]5(O[C@H](/C(C)=C/C(C)C)[C@@H](C)/C(C5)=N\OC)C4
InChi Code
InChI=1S/C37H53NO8/c1-21(2)14-25(6)33-26(7)31(38-42-8)19-36(46-33)18-29-17-28(45-36)13-12-23(4)15-22(3)10-9-11-27-20-43-34-32(39)24(5)16-30(35(40)44-29)37(27,34)41/h9-12,14,16,21-22,26,28-30,32-34,39,41H,13,15,17-20H2,1-8H3/b10-9+,23-12+,25-14+,27-11
InChi Key
YZBLFMPOMVTDJY-CBYMMZEQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $41

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    10 mg

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    25 mg

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    50 mg

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    Cayman Chemical
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    Product Description

    Moxidectin is a macrocyclic lactone endectocide and a derivative of nemadectin.1,2 It reduces fecal nematode egg counts by 98.4 and 99.8% in naturally infected calves when administered subcutaneously at doses of 0.2 and 0.3 mg/kg, respectively.2 Moxidectin (0.2 and 0.3 mg/kg) reduces the worm burden of O. ostertagi and T. axei in the abomasum, and Cooperia species and N. helvetianus in the small intestine, of naturally infected calves. It potentiates GABA-gated currents in Xenopus oocytes expressing rat α1β2γ2 subunit-containing GABAA receptors with an EC50 value of 11.8 nM.3 Formulations containing moxidectin have been used in the treatment of onchocerciasis, as well as in the prevention and treatment of parasitic infections in veterinary medicine.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kumar, A., Byun, H.S., Bittman, R., et al. The sphingolipid degradation product trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner. Cell. Signal. 23(7), 1144-1152 (2011).

    2. Ranjan, S., Trudeau, C., Prichard, R.K., et al. Efficacy of moxidectin against naturally acquired nematode infections in cattle. Vet. Parasitol. 41(3-4), 227-231 (1992).

    3. Ménez, C., Sutra, J.-F., Prichard, R., et al. Relative neurotoxicity of ivermectin and moxidectin in Mdr1ab (-/-) mice and effects on mammalian GABA(A) channel activity. PLoS Negl. Trop. Dis. 6(11), e1883 (2012).