A fluorinated fucose analog
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Product Categories

Product Type

Biochemicals

Research Area

Endocrinology & Metabolism
Carbohydrate Metabolism

2-deoxy-2-fluoro L-Fucose

Item No. 17171

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,6-dideoxy-2-fluoro-L-galactose
CAS Number
70763-62-1
Molecular Formula
C6H11FO4
Formula Weight
166.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 30 mg/mlEthanol: 0.25 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
C[C@H](O)[C@@H](O)[C@@H](O)[C@H](F)C=O
InChi Code
InChI=1S/C6H11FO4/c1-3(9)5(10)6(11)4(7)2-8/h2-6,9-11H,1H3/t3-,4?,5+,6-/m0/s1
InChi Key
SQTFKIKSQNCWGJ-CEZCPVKQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $202

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    10 mg

    $376

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    25 mg

    $876

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    Product Description

    2-deoxy-2-fluoro L-Fucose is a fluorinated fucose analog. It can be metabolized inside the cell to a substrate-based inhibitor of fucosyltransferases.1 Alternatively, it can be converted in vitro to GDP-2-deoxy-2-fluoro L-fucose, a competitive inhibitor of α1,3-fucosyltransferase V (Ki = 4.2 µM).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rillahan, C.D., Antonopoulos, A., Lefort, C.T., et al. Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome. Nat. Chem. Biol. 8(7), 661-668 (2012).

    2. Wong, C.H., and Hayashi, T. Process for preparing nucleotide inhibitors of glycosyltransferases. 763,227, (1998).