A mixture of colistins A and B
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Product Type

Biochemicals
Antibiotics
Polypeptides

Research Area

Colistin Methanesulfonate (sodium salt)

Item No. 17180

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
colistimethate, pentasodium salt
CAS Number
8068-28-8
Synonyms
  • Colimycin M
  • Polymyxin E sodium methanesulfonate
Molecular Formula
C58H105N16O28S5 • 5Na (for Colistin A)
Formula Weight
1749.8
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Water: 50 mg/ml
SMILES
CC[C@H](CCCCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1CCNC([C@H]([C@H](O)C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](NC([C@@H](NC1=O)CCNCS([O-])(=O)=O)=O)CC(C)C)=O)CC(C)C)=O)CCNCS([O-])(=O)=O)=O)CCNCS([O-])(=O)=O)=O)=O)=O)CCNCS([O-])(=O)=O)=O)[C@H](O)C)=O)CCNCS([O-])(=O)=O)=O)C.CC(CCCCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2CCNC([C@H]([C@H](O)C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](NC([C@@H](NC2=O)CCNCS([O-])(=O)=O)=O)CC(C)C)=O)CC(C)C)=O)CCNCS([O-])(=O)=O)=O)CCNCS([O-])(=O)=O)=O)=O)=O)CCNCS([O-])(=O)=O)=O)[C@H](O)C)=O)CCNCS([O-])(=O)=O)=O)C.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C58H110N16O28S5.C57H108N16O28S5.10Na/c1-9-35(6)12-10-11-13-46(77)65-38(14-20-59-28-103(88,89)90)53(82)74-48(37(8)76)58(87)70-41(17-23-62-31-106(97,98)99)50(79)68-43-19-25-64-57(86)47(36(7)75)73-54(83)42(18-24-63-32-107(100,101)102)67-49(78)39(15-21-60-29-104(91,92)93)69-55(84)44(26-33(2)3)72-56(85)45(27-34(4)5)71-52(81)40(66-51(43)80)16-22-61-30-105(94,95)96;1-32(2)11-9-10-12-45(76)64-37(13-19-58-27-102(87,88)89)52(81)73-47(36(8)75)57(86)69-40(16-22-61-30-105(96,97)98)49(78)67-42-18-24-63-56(85)46(35(7)74)72-53(82)41(17-23-62-31-106(99,100)101)66-48(77)38(14-20-59-28-103(90,91)92)68-54(83)43(25-33(3)4)71-55(84)44(26-34(5)6)70-51(80)39(65-50(42)79)15-21-60-29-104(93,94)95;;;;;;;;;;/h33-45,47-48,59-63,75-76H,9-32H2,1-8H3,(H,64,86)(H,65,77)(H,66,80)(H,67,78)(H,68,79)(H,69,84)(H,70,87)(H,71,81)(H,72,85)(H,73,83)(H,74,82)(H,88,89,90)(H,91,92,93)(H,94,95,96)(H,97,98,99)(H,100,101,102);32-44,46-47,58-62,74-75H,9-31H2,1-8H3,(H,63,85)(H,64,76)(H,65,79)(H,66,77)(H,67,78)(H,68,83)(H,69,86)(H,70,80)(H,71,84)(H,72,82)(H,73,81)(H,87,88,89)(H,90,91,92)(H,93,94,95)(H,96,97,98)(H,99,100,101);;;;;;;;;;/q;;10*+1/p-10/t35-,36-,37-,38+,39+,40+,41+,42+,43+,44+,45-,47+,48+;35-,36-,37+,38+,39+,40+,41+,42+,43+,44-,46+,47+;;;;;;;;;;/m11........../s1
InChi Key
GORAPWMSIIZXKA-MQWOGWDMSA-D
Shipping & Storage Information
Storage
4°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

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    Product Description

    Colistin methanesulfonate is a mixture of the cyclic polypeptide antibiotics colistin A and colistin B.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Suzuki, T., Inouye, H., Fujikawa, K., et al. Studies on the chemical structure of colistin. I. Fractionation, molecular weight determination, amino acid and fatty acid composition. J. Biochem. 54(1), 25-33 (1963).

    2. Dotsikas, Y., Markopoulou, C.K., Koundourellis, J.E., et al. Validation of a novel LC-MS/MS method for the quantitation of colistin A and B in human plasma. J. Sep. Sci. 34(1), 37-45 (2011).