A non-denaturing nonionic detergent
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n-Octyl-β-D-thioglucopyranoside

Item No. 17184

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
octyl 1-thio-β-D-glucopyranoside
CAS Number
85618-21-9
Synonyms
  • Octylthioglucoside
  • OTG
Molecular Formula
C14H28O5S
Formula Weight
308.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 15 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
O[C@@H]1[C@@H](O)[C@H](SCCCCCCCC)O[C@H](CO)[C@H]1O
InChi Code
InChI=1S/C14H28O5S/c1-2-3-4-5-6-7-8-20-14-13(18)12(17)11(16)10(9-15)19-14/h10-18H,2-9H2,1H3/t10-,11-,12+,13-,14+/m1/s1
InChi Key
CGVLVOOFCGWBCS-RGDJUOJXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $36

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    1 g

    $49

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    5 g

    $203

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    10 g

    $336

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    Product Description

    n-Octyl-β-D-thioglucopyranoside (OTG) is a low molecular weight nonionic detergent that is commonly used for cell lysis and non-denaturing protein solubilization.1,2 It has a critical micelle concentration of 7.9-9.0 mM.1,3 OTG is stable in aqueous solutions, resistant to degradation by β-glucosidases, and easily removed by dialysis.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Saito, S., and Tsuchiya, T. Characteristics of n-octyl β-D-thioglucopyranoside, a new non-ionic detergent useful for membrane biochemistry. Biochem. J. 222(3), 829-832 (1984).

    2. Tsuchiya, T., and Saito, S. Use of n-octyl-β-D-thioglucoside, a new nonionic detergent, for solubilization and reconstitution of membrane proteins. J. Biochem. 96(5), 1593-1597 (1984).

    3. Ruiz, C.C., Molina-Bolívar, J.A., hierrezuelo, J.M., et al. Self-assembly, surface activity and structure of n-octyl-β-D-thioglucopyranoside in ethylene glycol-water mixtures. Int. J. Mol. Sci. 14(2), 3228-3253 (2013).