An inhibitor of GAC
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Glutaminase Inhibitor Compound 968

Item No. 17199

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
12-[3-bromo-4-(dimethylamino)phenyl]-8,9,10,12-tetrahydro-9,9-dimethyl-benz[a]acridin-11(7H)-one
CAS Number
442660-67-5
Molecular Formula
C27H27BrN2O
Formula Weight
475.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMF:PBS (pH 7.2) (1:2): 0.3 mg/mlDMSO: 14 mg/mlEthanol: 0.5 mg/ml
λmax
216, 232, 281, 292, 339, 371 nm
SMILES
O=C1C2=C(CC(C)(C1)C)NC3=C(C2C4=CC=C(N(C)C)C(Br)=C4)C5=C(C=CC=C5)C=C3
InChi Code
InChI=1S/C27H27BrN2O/c1-27(2)14-21-26(23(31)15-27)24(17-10-12-22(30(3)4)19(28)13-17)25-18-8-6-5-7-16(18)9-11-20(25)29-21/h5-13,24,29H,14-15H2,1-4H3
InChi Key
QQOIOWZZAMRXJU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

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    10 mg

    $135

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    25 mg

    $294

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    Cayman Chemical
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    Product Description

    Glutaminase inhibitor compound 968 (968) is an inhibitor of glutaminase C (GAC; IC50 = 9.3 µM).1 It was previously proposed that 968 contained a benzo[c]phenanthridine structure, but it was later shown that the correct structure contains the isomeric benzo[c]acridine.2,3 968 inhibits the proliferation and invasion of, and induces apoptosis in, MDA-MB-231 breast cancer cells at 10 µM.1,4 It also inhibits viral replication in Vero E6 cells infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at 2.5 µM.5 In vivo, 968 reduces tumor volume in a P493 B cell lymphoma mouse xenograft model.2 This product has been verified to contain the benzo[c]acridine structure.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Katt, W.P., Ramachandran, S., Erickson, J.W., et al. Dibenzophenanthridines as inhibitors of glutaminase C and cancer cell proliferation. Mol. Cancer Ther. 11(6), 1269-1278 (2012).

    2. Wang, J.-B., Erickson, J.W., Fuji, R., et al. Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell 18(3), 2007-2219 (2010).

    3. Albertelli, L.A., Jallow, S., Li, C., et al. Structural reassignment of compund 968, an allosteric glutaminase inhibitor. Beilstein J. Org. Chem. 22, 455-460 (2026).

    4. Simpson, N.E., Tryndyak, V.P., Pogribna, M., et al. Modifying metabolically sensitive histone marks by inhibiting glutamine metabolism affects gene expression and alters cancer cell phenotype. Epigenetics 7(12), 1413-1420 (2012).

    5. Greene, K.S., Choi, A., Yang, N., et al. Glutamine metabolism is essential for coronavirus replication in host cells and in mice. The Journal of Biological Chemisty 301(1), 108063 (2025).