An inducer of reactivation of mutant p53
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PK7242 (maleate)

Item No. 17230

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(4-(4-fluorophenyl)-3-(1H-pyrrol-1-yl)-1H-pyrazol-1-yl)-N,N-dimethylethan-1-amine, 2Z-butenedioate
Molecular Formula
C17H19FN4 • C4H4O4
Formula Weight
414.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 16 mg/mlEthanol: 3 mg/mlPBS (pH 7.2): 2 mg/ml
SMILES
FC(C=C1)=CC=C1C2=CN(CCN(C)C)N=C2N3C=CC=C3.OC(/C=C\C(O)=O)=O
InChi Code
InChI=1S/C17H19FN4.C4H4O4/c1-20(2)11-12-22-13-16(14-5-7-15(18)8-6-14)17(19-22)21-9-3-4-10-21;5-3(6)1-2-4(7)8/h3-10,13H,11-12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChi Key
JFMPWCFBSHSNCA-BTJKTKAUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    500 µg

    $63

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    1 mg

    $118

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    5 mg

    $454

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    Cayman Chemical
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    Product Description

    PK7242 is an inducer of reactivation of mutant p53 in cancer cells. In cancer cells carrying the Y220C mutant, PK7242 binds to the p53-Y220C core domain and induces growth inhibition, cell-cycle arrest, and apoptosis.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, X., Wilcken, R., Joerger, A.C., et al. Small molecule induced reactivation of mutant p53 in cancer cells. Nucleic Acids Res. 41(12), 6034-6044 (2013).