An orally active inhibitor of sPLA2-IIA
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sPLA2 Inhibitor

Item No. 17277

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
γS-[(1-oxo-7-phenylheptyl)amino]-4-(phenylmethoxy)-benzenepentanoic acid
CAS Number
393569-31-8
Synonyms
  • KH064
  • Secretory Phospholipase A2 Inhibitor
Molecular Formula
C31H37NO4
Formula Weight
487.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 2 mg/mlEthanol: 5 mg/mlEthanol:PBS (pH 7.2) (1:6): 0.1 mg/ml
SMILES
O=C(CCCCCCC1=CC=CC=C1)N[C@@H](CCC(O)=O)CC(C=C2)=CC=C2OCC3=CC=CC=C3
InChi Code
InChI=1S/C31H37NO4/c33-30(16-10-2-1-5-11-25-12-6-3-7-13-25)32-28(19-22-31(34)35)23-26-17-20-29(21-18-26)36-24-27-14-8-4-9-15-27/h3-4,6-9,12-15,17-18,20-21,28H,1-2,5,10-11,16,19,22-24H2,(H,32,33)(H,34,35)/t28-/m0/s1
InChi Key
KWLUIYFCMHKLKY-NDEPHWFRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $41

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    1 mg

    $72

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    5 mg

    $293

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    10 mg

    $544

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    Product Description

    sPLA2 inhibitor is an orally active inhibitor of sPLA2-IIA.1 It protects against intestinal reperfusion injury in rats when given at 10 mg/kg orally.1 sPLA2 inhibitor also attenuates NF-κB signaling in lung cancer cells and protects against diet-induced metabolic syndrome in rats.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Arumugam, T.V., Arnold, N., Proctor, L.M., et al. Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist. Br. J. Pharmacol. 140(1), 71-80 (2003).

    2. Yu, J.A., Kalatardi, S., Dohse, J., et al. Group IIa sPLA2 inhibition attenuates NF-κB activity and promotes apoptosis of lung cancer cells. Anticancer Res. 32(9), 3601-3607 (2012).

    3. Iyer, A., Lim, J., Poudyal, H., et al. An inhibitor of phospholipase A2 group IIA modulates adipocyte signaling and protects against diet-induced metabolic syndrome in rats. Diabetes 61(9), 2320-2329 (2012).

    Product Citations

    Ling, H., Jia, X., Zhang, Y., et al. Pachymic acid inhibits cell growth and modulates arachidonic acid metabolism in nonsmall cell lung cancer A549 cells. Mol. Carcinog. 49(3), 271-282 (2010).