A Cdc25 phosphatase inhibitor
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DA-3003-2

Item No. 17282

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-chloro-6-[[2-(4-morpholinyl)ethyl]amino]-5,8-quinolinedione
CAS Number
383907-47-9
Synonyms
  • NSC 663285
Molecular Formula
C15H16ClN3O3
Formula Weight
321.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/ml
λmax
233, 272, 477 nm
SMILES
O=C(C(NCCN1CCOCC1)=C2Cl)C3=C(N=CC=C3)C2=O
InChi Code
InChI=1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)14(20)10-2-1-3-17-12(10)15(11)21/h1-3,18H,4-9H2
InChi Key
LGTBDMBBPVNDSZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $69

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    5 mg

    $297

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    10 mg

    $525

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    25 mg

    $1,062

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    Cayman Chemical
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    Product Description

    Cdc25 dual-specific protein tyrosine phosphatases are important for cell cycle progression and often overexpressed in cancers. Through the removal of inhibitory phosphates, they function to catalyze the activation of cyclin-Cdk complexes. DA-3003-2 is a Cdc25 phosphatase inhibitor (IC50 = 0.82 µM for human recombinant Cdc25B) that demonstrates antiproliferative activity.1,2,3 At 20 µM, it has been shown to arrest asynchronous PC-3 prostate cancer cells in G2/M phase.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lazo, J.S., Aslan, D.C., Southwick, E.C., et al. Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25. J. Med. Chem. 44(24), 4042-4049 (2001).

    2. Lavecchia, A., Cosconati, S., Limongelli, V., et al. Modeling of Cdc25B dual specifity protein phosphatase inhibitors: Docking of ligands and enzymatic inhibition mechanism. ChemMedChem 1(5), 540-550 (2006).

    3. Nemoto, K. G2/M accumulation in prostate cancer cell line PC-3 is induced by Cdc25 inhibitor 7-chloro-6-(2-morpholin-4-ylethylamino) quinoline-5, 8-dione (DA 3003-2). Exp. Ther. Med. 1(4), 647-650 (2010).