An inhibitor of heparanase
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OGT 2115

Item No. 17324

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[4-[[3-(4-bromophenyl)-1-oxo-2-propen-1-yl]amino]-3-fluorophenyl]-5-benzoxazoleacetic acid
CAS Number
853929-59-6
Molecular Formula
C24H16BrFN2O4
Formula Weight
495.3
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
BrC1=CC=C(/C=C/C(NC2=C(F)C=C(C3=NC4=C(C=CC(CC(O)=O)=C4)O3)C=C2)=O)C=C1
InChi Code
InChI=1S/C24H16BrFN2O4/c25-17-6-1-14(2-7-17)4-10-22(29)27-19-8-5-16(13-18(19)26)24-28-20-11-15(12-23(30)31)3-9-21(20)32-24/h1-11,13H,12H2,(H,27,29)(H,30,31)/b10-4+
InChi Key
LKBXWNYXDMSFQU-ONNFQVAWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $134

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    10 mg

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    25 mg

    $498

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    Cayman Chemical
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    Product Description

    OGT 2115 is an inhibitor of heparanase (IC50 = 0.4 µM), an enzyme that cleaves heparan sulfate into glucuronic acid (GlcUA) and N-acetylglucosamine (GlcNAc).1,2 OGT 2115 (10 µM) inhibits herpes simplex virus 2 (HSV-2) infection of VK2/E6E7 vaginal epithelial cells.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Courtney, S.M., Hay, P.A., Buck, R.T., et al. Furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acid derivatives: Novel classes of heparanase inhibitor. Bioorg. Med. Chem. Lett. 15(9), 2295-2299 (2005).

    2. Nishimura, Y., Shitara, E., Adachi, H., et al. Flexible synthesis and biological activity of uronic acid-type gem-diamine 1-N-iminosugars: A new family of glycosidase inhibitors. The Journal of Organic Chemistry 65(1), 2-11 (2000).

    3. Hopkins, J., Yadavalli, T., Agelidis, A.M., et al. Host enzymes heparanase and cathepsin L promote herpes simplex virus 2 release from cells. J. Virol. 92(23), e01179-e01218 (2018).