A light-activated chlorin
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Temoporfin

Item No. 17333

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,3',3'',3'''-(7,8-dihydro-21H,23H-porphine-5,10,15,20-tetrayl)tetrakis-phenol
CAS Number
122341-38-2
Synonyms
  • Foscan
  • KW 2345
  • m-THPC
Molecular Formula
C44H32N4O4
Formula Weight
680.8
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/mlEthanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
λmax
284, 416, 516, 542, 596, 650 nm
SMILES
OC1=CC(/C2=C3[NH]/C(C=C/3)=C(C4=CC=CC(O)=C4)\C5=[N]/C(C=C5)=C(C6=CC(O)=CC=C6)\C7=CC=C(/C(C8=CC(O)=CC=C8)=C9[N]=C2CC\9)[NH]7)=CC=C1
InChi Code
InChI=1S/C44H32N4O4/c49-29-9-1-5-25(21-29)41-33-13-15-35(45-33)42(26-6-2-10-30(50)22-26)37-17-19-39(47-37)44(28-8-4-12-32(52)24-28)40-20-18-38(48-40)43(36-16-14-34(41)46-36)27-7-3-11-31(51)23-27/h1-17,19,21-24,46-47,49-52H,18,20H2/b41-33-,41-34-,42-3
InChi Key
LYPFDBRUNKHDGX-LWQDQPMZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $36

    Add

    5 mg

    $153

    Add

    10 mg

    $268

    Add

    25 mg

    $587

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Temoporfin is a synthetic chlorin with light-activated actions. When administered systemically, temoporfin accumulates in tumor cells.1,2 When stimulated with light (650-652 nm) in the presence of oxygen, reactive oxygen species are generated, leading to necrosis within the tumor.1,2 Different approaches to using photodynamic therapy with temoporfin in palliative care are currently of interest.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Alian, W., Andersson-Engels, S., Svanberg, K., et al. Laser-induced fluorescence studies of meso-tetra(hydroxyphenyl)chlorin in malignant and normal tissues in rats. Br. J. Cancer 70(5), 880-885 (1994).

    2. Ris, H.B., Altermatt, H.J., Inderbitzi, R., et al. Photodynamic therapy with chlorins for diffuse malignant mesothelioma: Initial clinical results. Br. J. Cancer 64(6), 1116-1120 (1991).

    3. Reshetov, V., Lassalle, H.P., François, A., et al. Photodynamic therapy with conventional and PEGylated liposomal formulations of mTHPC (temoporfin): Comparison of treatment efficacy and distribution characteristics in vivo. Int. J. Nanomedicine 8, 3817-3831 (2013).

    4. Succo, G., Rosso, S., Fadda, G.L., et al. Salvage photodynamic therapy for recurrent nasopharyngeal carcinoma. Photodiagnosis Photodyn.Ther. 11(2), 63-70 (2014).