A vasopressin receptor agonist
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Desmopressin (trifluoroacetate salt)

Item No. 17348

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(3-mercapto-1-oxopropyl)-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-D-arginyl-glycinamide, cyclic (1→5)-disulfide, trifluoroacetate salt
Synonyms
  • Adiuretin
  • DDAVP
Molecular Formula
C46H64N14O12S2 • XCF3COOH
Formula Weight
1069.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 5 mg/mlPBS (pH 7.2): 2 mg/ml
SMILES
NC(CNC([C@@H](CCCNC(N)=N)NC([C@@H]1CCCN1C([C@H](CSSCCC(N[C@@H](CC2=CC=C(O)C=C2)C3=O)=O)NC([C@H](CC(N)=O)NC([C@@H](NC([C@@H](N3)CC4=CC=CC=C4)=O)CCC(N)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C46H64N14O12S2.C2HF3O2/c47-35(62)15-14-29-40(67)58-32(22-36(48)63)43(70)59-33(45(72)60-18-5-9-34(60)44(71)56-28(8-4-17-52-46(50)51)39(66)53-23-37(49)64)24-74-73-19-16-38(65)54-30(21-26-10-12-27(61)13-11-26)41(68)57-31(42(69)55-29)20-25-6-2-1-3-7-25;3-2(4,5)1(6)7/h1-3,6-7,10-13,28-34,61H,4-5,8-9,14-24H2,(H2,47,62)(H2,48,63)(H2,49,64)(H,53,66)(H,54,65)(H,55,69)(H,56,71)(H,57,68)(H,58,67)(H,59,70)(H4,50,51,52);(H,6,7)/t28-,29+,30+,31+,32+,33+,34+;/m1./s1
InChi Key
SSJRGONHCCPVKV-IFHOVBQLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    500 µg

    $49

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    1 mg

    $82

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    5 mg

    $329

    Add
    Product Description

    Desmopressin is a synthetic version of the endogenous antidiuretic hormone arginine vasopressin (AVP). Compared to AVP, the first amino acid of desmopressin has been deaminated, and the arginine at the eighth position is in the dextrorotatory rather than the levorotatory form. Desmopressin acts as an agonist at human vasopressin V1a, V1b, and V2 receptors with Ki values of 62.4, 5.8, and 23.3 nM, respectively.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cheng, L.L., Stoev, S., Manning, M., et al. Design of potent and selective agonists for the human vasopressin V1b receptor based on modifications of [deamino-cys1]arginine vasopressin at position 4. J. Med. Chem. 47(9), 2375-2388 (2004).