An inhibitor of IRE1 endonuclease activity
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STF-083010

Item No. 17370

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(2-hydroxy-naphthalenyl)methylene]-2-thiophenesulfonamide
CAS Number
307543-71-1
Synonyms
  • IRE1 Inhibitor I
Molecular Formula
C15H11NO3S2
Formula Weight
317.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMF:PBS (pH 7.2) (1:7): 0.12 mg/mlDMSO: 1 mg/ml
λmax
224, 249, 338, 384 nm
SMILES
O=S(/N=C/C1=C2C(C=CC=C2)=CC=C1O)(C3=CC=CS3)=O
InChi Code
InChI=1S/C15H11NO3S2/c17-14-8-7-11-4-1-2-5-12(11)13(14)10-16-21(18,19)15-6-3-9-20-15/h1-10,17H/b16-10+
InChi Key
TVIVJHZHPKNDAQ-MHWRWJLKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    25 mg

    $182

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    Product Description

    STF-083010 is an inhibitor of the IRE1/XBP1 pathway, blocking IRE1 endonuclease activity without affecting its kinase activity after endoplasmic reticulum (ER) stress both in vitro and in vivo.1 STF-083010 (60 µM) reduces the splicing of XBP1 by IRE1 in the presence of thapsigargin (Item No. 10522), an ER stress inducer.1 This has cytotoxic effects against multiple myeloma cells and drives apoptosis in pancreatic cancer cells.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Papandreou, I., Denko, N.C., Olson, M., et al. Identification of an Ire1 alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. Blood 117(4), 1311-1314 (2011).

    2. Chien, W., Ding, L.W., Sun, Q.Y., et al. Selective inhibition of unfolded protein response induces apoptosis in pancreatic cancer cells. Oncotarget 5(13), 4881-4894 (2014).