Potent, selective PI3Kδ inhibitor
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AMG 319

Item No. 17383

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-fluoro-αS-methyl-N-9H-purin-6-yl-2-(2-pyridinyl)-3-quinolinemethanamine
CAS Number
1608125-21-8
Molecular Formula
C21H16FN7
Formula Weight
385.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mLDMSO: 5 mg/mLDMSO:PBS(pH 7.2) (1:4): 0.2 mg/mLEthanol: 3 mg/mL
λmax
267 nm
SMILES
C[C@@H](C1=CC(C=CC(F)=C2)=C2N=C1C3=CC=CC=N3)NC4=C5C(N=CN5)=NC=N4
InChi Code
InChI=1S/C21H16FN7/c1-12(28-21-19-20(25-10-24-19)26-11-27-21)15-8-13-5-6-14(22)9-17(13)29-18(15)16-4-2-3-7-23-16/h2-12H,1H3,(H2,24,25,26,27,28)/t12-/m0/s1
InChi Key
KWRYMZHCQIOOEB-LBPRGKRZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $153

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    10 mg

    $268

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    25 mg

    $502

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    Product Description

    AMG 319 is a potent inhibitor of phosphatidylinositol 3-kinase (PI3K) isoform δ (PI3Kδ; IC50 = 18 nM) that less effectively targets the α, β, and γ isoforms (IC50s = 33, 2.7, and 0.85 µM, respectively).1 It blocks anti-IgM/CD40L-induced proliferation (IC50 = 8.6 nM) and reduces Akt phosphorylation (IC50 = 1.5 nM) in B cells.1 AMG 319 is orally bioavailable and reduces inflammation in two animal models.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cushing, T.D., Hao, X., Shin, Y., et al. Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease. J. Med. Chem. 58(1), 480-511 (2015).