A selective partial agonist for GPR120
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Grifolic Acid

Item No. 17398

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,4-dihydroxy-6-methyl-3-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]-benzoic acid
CAS Number
80557-12-6
Molecular Formula
C23H32O4
Formula Weight
372.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 100mg/mL
λmax
221, 268, 303 nm
SMILES
OC1=C(C/C=C(CC/C=C(C)/CC/C=C(C)\C)\C)C(O)=CC(C)=C1C(O)=O
InChi Code
InChI=1S/C23H32O4/c1-15(2)8-6-9-16(3)10-7-11-17(4)12-13-19-20(24)14-18(5)21(22(19)25)23(26)27/h8,10,12,14,24-25H,6-7,9,11,13H2,1-5H3,(H,26,27)/b16-10+,17-12+
InChi Key
QPIZDZGIXDKCRC-JTCWOHKRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $95

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    1 mg

    $168

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    Product Description

    Grifolic acid is a selective partial agonist of GPR120 that induces ERK activation and intracellular calcium responses in mouse enteroendocrine STC-1 cells that express GPR120 endogenously, but not those expressing GPR40.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sun, Q., Hirasawa, A., Hara, T., et al. Structure-activity relationships of GPR120 agonists based on a docking simulation. Mol. Pharm. 78(5), 804-810 (2010).