A precursor of phytanic acid
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Phytol

Item No. 17401

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,7,11,15-tetramethyl-2-hexadecen-1-ol
CAS Number
7541-49-3
Molecular Formula
C20H40O
Formula Weight
296.5
Purity
≥85% (mixture of isomers)
Formulation (Request formulation change)
A neat oil
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 5 mg/mlEthanol: 10 mg/ml
SMILES
CC(CCCC(C)CCCC(C)CCC/C(C)=C/CO)C
InChi Code
InChI=1S/C20H40O/c1-17(2)9-6-10-18(3)11-7-12-19(4)13-8-14-20(5)15-16-21/h15,17-19,21H,6-14,16H2,1-5H3/b20-15+
InChi Key
BOTWFXYSPFMFNR-HMMYKYKNSA-N
Origin
Plant/Mulberry leaf
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 g

    $61

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    50 g

    $85

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    100 g

    $135

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    250 g

    $307

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    Product Description

    Phytol is a diterpene alcohol obtained from the degradation of chlorophyll and has been used in the synthesis of Vitamins E and K. During the digestion process of ruminants, phytol is liberated from chlorophyll and converted to phytanic acid (Item No. 90360) to be stored in fats. While humans cannot derive phytol from chlorophyll, free phytol, obtained from the consumption of ruminant adipose tissue and dairy products, is readily absorbed in the small intestine and converted to phytanic acid.1 Phytanic acid accumulates to toxic levels in a number of metabolic disorders, and the conversion of phytol to phytanic acid has been shown to be regulated via the activation of peroxisome proliferator-activated receptor α (PPARα).2,1 Phytol and its metabolites have also been reported to activate retinoid X receptors (RXRs; Kis range from 2.3-67.2 µM) and to promote the activity of PPAR/RXR heterodimers.3,2 Phytol also demonstrates sedative and anxiolytic effects through interaction with the GABAA receptor, and it has been explored as an antischistosomal agent in a mouse model of schistosomiasis.4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gloerich, J., van den Brink, D.M., Ruiter, J.P.N., et al. Metabolism of phytol to phytanic acid in the mouse, and the role of PPARα in its regulation. J. Lipid Res. 48(1), 77-85 (2007).

    2. Elmazar, M.M., El-Abhar, H.S., Schaalen, M.F., et al. Phytol/Phytanic acid and insulin resistance: Potential role of phytanic acid proven by docking simulation and modulation of biochemical alterations. PLoS One 8(1), 1-10 (2013).

    3. Kitareewan, S., Burka, L.T., Tomer, K.B., et al. Phytol metabolites are circulating dietary factors that activate the nuclear receptor RXR. Mol. Biol. Cell 7(8), 1153-1166 (1996).

    4. Costa, J.P., de Oliveira, G.A., de Almeida, A.A., et al. Anxiolytic-like effects of phytol: Possible involvement of GABAergic transmission. Brain Res. 1547, 34-42 (2014).

    5. de Moraes, J., de Oliveira, R.N., Costa, J.P., et al. Phytol, a diterpene alcohol from chlorophyll, as a drug against neglected tropical disease Schistosomiasis mansoni. PLoS One 8(1), 1-12 (2014).