A potent, selective agonist of α7-containing nAChRs
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

PNU 282987

Item No. 17424

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-benzamide
CAS Number
711085-63-1
Molecular Formula
C14H17ClN2O
Formula Weight
264.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 30 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
237 nm
SMILES
O=C(C1=CC=C(Cl)C=C1)N[C@@H]2C(CC3)CCN3C2
InChi Code
InChI=1S/C14H17ClN2O/c15-12-3-1-11(2-4-12)14(18)16-13-9-17-7-5-10(13)6-8-17/h1-4,10,13H,5-9H2,(H,16,18)/t13-/m0/s1
InChi Key
WECKJONDRAUFDD-ZDUSSCGKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $50

    Add

    10 mg

    $94

    Add

    25 mg

    $183

    Add

    50 mg

    $339

    Add
    Product Description

    PNU 282987 is a potent agonist of α7-containing neuronal nicotinic acetylcholine receptors (nAChRs; Ki = 26 nM for the rat receptor).1 It has negligible activity against α1β1γδ and α3β4 nAChRs as well as a panel of monoamine, muscarinic, glutamate, and GABA receptors, except 5-HT3 (Ki = 930 nM).1 PNU 282987 evokes whole-cell currents from cultured rat hippocampal neurons and enhances GABAergic synaptic activity when applied to hippocampal slices.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bodnar, A.L., Cortes-Burgos, L.A., Cook, K.K., et al. Discovery and structure-activity relationship of quinuclidine benzamides as agonists of α7 nicotinic acetylcholine receptors. J. Med. Chem. 48(4), 905-908 (2005).

    2. Hajós, M., Hurst, R.S., Hoffmann, W.E., et al. The selective α7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetized rats. J. Pharmacol. Exp. Ther. 312(3), 1213-1222 (2005).

    Product Citations

    Isotani, R., Igarashi, M., Miura, M., et al. Nicotine enhances the stemness and tumorigenicity in intestinal stem cells via Hippo-YAP/TAZ and Notch signal pathway. Elife 13, RP95267 (2025).