A lipoprotein lipase activator
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NO-1886

Item No. 17425

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[[4-[[(4-bromo-2-cyanophenyl)amino]carbonyl]phenyl]methyl]-phosphonic acid diethyl ester
CAS Number
133208-93-2
Synonyms
  • Ibrolipim
  • Lipoprotein Lipase Activator
  • LPL Activator
  • OPF 009
Molecular Formula
C19H20BrN2O4P
Formula Weight
451.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 25 mg/mlEthanol: 2 mg/ml
λmax
260 nm
SMILES
BrC1=CC(C#N)=C(NC(C2=CC=C(CP(OCC)(OCC)=O)C=C2)=O)C=C1
InChi Code
InChI=1S/C19H20BrN2O4P/c1-3-25-27(24,26-4-2)13-14-5-7-15(8-6-14)19(23)22-18-10-9-17(20)11-16(18)12-21/h5-11H,3-4,13H2,1-2H3,(H,22,23)
InChi Key
KPRTURMJVWXURQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $95

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    10 mg

    $169

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    25 mg

    $378

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    Product Description

    NO-1886 is an LPL activator that increases LPL mRNA and LPL activity in adipose tissue, myocardium, and skeletal muscle.1 This coincides with an elevation in post-heparin plasma LPL activity and LPL mass in rats.1,2 NO-1886 decreases plasma triglyceride concentration and increases plasma high-density lipoprotein cholesterol, resulting in inhibited development of atherosclerotic lesions in coronary arteries and aortas of rats and rabbits.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yin, W., and Tsutsumi, K. Lipoprotein lipase activator NO-1886. Cardiovasc. Drug Rev. 21(2), 133-142 (2003).

    2. Tsutsumi, K., Inoue, Y., Shima, A., et al. The novel compound NO-1886 increases lipoprotein lipase activity with resulting elevation of high density lipoprotein cholesterol, and long-term administration inhibits atherogenesis in the coronary arteries of rats with experimental atherosclerosis. J. Clin. Invest. 92(1), 411-417 (1993).