An affinity probe for citrullinated proteins
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Citrulline-specific Probe-biotin

Item No. 17450

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3aR,4R,6aS)-rel-hexahydro-N-[2-[[4-[1-[1-methyl-2-oxo-2-[[3-(2-oxoacetyl)phenyl]amino]ethyl]-1H-1,2,3-triazol-4-yl]-1-oxobutyl]amino]ethyl]-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide
CAS Number
2468149-70-2
Molecular Formula
C29H38N8O6S
Formula Weight
626.7
Purity
≥75%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
CC(C(NC1=CC(C(C([H])=O)=O)=CC=C1)=O)N2N=NC(CCCC(NCCNC(CCCC[C@@H]3SC[C@@](N4)([H])[C@]3([H])NC4=O)=O)=O)=C2
InChi Code
InChI=1S/C29H38N8O6S/c1-18(28(42)32-20-7-4-6-19(14-20)23(39)16-38)37-15-21(35-36-37)8-5-11-26(41)31-13-12-30-25(40)10-3-2-9-24-27-22(17-44-24)33-29(43)34-27/h4,6-7,14-16,18,22,24,27H,2-3,5,8-13,17H2,1H3,(H,30,40)(H,31,41)(H,32,42)(H2,33,34,43)/t18?,2
InChi Key
ROSSMRMVAUYSKN-LTKSESKGSA-N
License
Sold under license from The Scripps Research Institute.
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    500 µg

    $336

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    1 mg

    $597

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    Product Description

    Citrulline-specific probe-biotin is an affinity probe that allows for detection or immobilization of citrullinated proteins through interaction with the biotin ligand. It contains a phenylglyoxal group that selectively labels citrulline over arginine at acidic pH.1 Citrulline-specific probe-biotin is a biotinylated form of citrulline-specific probe-rhodamine (Item No. 16172) that contains biotin in place of the rhodamine fluorophore.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bicker, K.L., Subramanian, V., Chumanevich, A.A., et al. Seeing citrulline: Development of a phenylglyoxal-based probe to visualize protein citrullination. J. Am. Chem. Soc. 134(41), 17015-17018 (2012).

    Product Citations

    Pitter, M.R., Kryczek, I., Zhang, H., et al. PAD4 controls tumor immunity via restraining the MHC class II machinery in macrophages. Cell Rep. 43(3), 113942 (2024).