NF-κB Control

NF-κB inhibitor (Item No. 17493) is a synthetic peptide corresponding to the nuclear localization sequence (NLS) of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells.¹ It blocks the nuclear import of p105 in cells treated with activators of NF-κB signaling, including LPS and TNF-α.¹ NF-κB control is a peptide that is identical in sequence to NF-κB inhibitor, except two essential, basic residues of the p105 NLS are substituted with non-basic amino acids.¹ It is ineffective at blocking the activation of NF-κB signaling and is used as a negative control peptide.^1,2,3

WARNING This product is not for human or veterinary use.

1. Lin, Y.Z., Tao, S., Veach, R.A., et al. Inhibition of nuclear translocation of transcription factor NF-κB by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence. The Journal of Biological Chemisty 270(24), 14255-14258 (1995).

2. Pahan, K., Sheikh, F.G., Liu, X., et al. Induction of nitric-oxide synthase and activation of NF-κB by interleukin-12 p40 in microglial cells. The Journal of Biological Chemisty 276(11), 7899-7905 (2001).

3. Kang, Y.M., Gao, F., Li, H.H., et al. NF-κB in the paraventricular nucleus modulates neurotransmitters and contributes to sympathoexcitation in heart failure. Basic Res. Cardiol. 106(6), 1087-1097 (2011).