A peptide substrate of Cdk5
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Cdk5 Substrate (trifluoroacetate salt)

Item No. 17477

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-prolyl-L-lysyl-L-threonyl-L-prolyl-L-lysyl-L-lysyl-L-alanyl-L-lysyl-L-lysyl-L-leucine, trifluoroacetate salt
Synonyms
  • Cyclin-dependent kinase 5 Substrate
Molecular Formula
C53H99N15O12 • XCF3COOH
Formula Weight
1138.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Peptide Sequence
PKTPKKAKKL-OH
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 20 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
[H]N1CCC[C@H]1C(N[C@@H](CCCCN)C(N[C@]([C@@H](C)O)([H])C(N2CCC[C@H]2C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C53H99N15O12.C2HF3O2/c1-32(2)31-41(53(79)80)66-49(75)38(19-7-12-26-56)64-47(73)37(18-6-11-25-55)61-44(70)33(3)60-46(72)36(17-5-10-24-54)63-48(74)39(20-8-13-27-57)65-51(77)42-23-16-30-68(42)52(78)43(34(4)69)67-50(76)40(21-9-14-28-58)62-45(71)35-22-15-29-59-35;3-2(4,5)1(6)7/h32-43,59,69H,5-31,54-58H2,1-4H3,(H,60,72)(H,61,70)(H,62,71)(H,63,74)(H,64,73)(H,65,77)(H,66,75)(H,67,76)(H,79,80);(H,6,7)/t33-,34+,35-,36-,37-,38-,39-,40-,41-,42-,43-;/m0./s1
InChi Key
RAKPKHOVQLWLRB-ZCKAZPTLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $63

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    1 mg

    $105

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    5 mg

    $423

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    10 mg

    $662

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    Product Description

    Cdk5 is a serine/threonine kinase that is predominantly active in neuronal tissues. With p25 or p35, Cdk5 phosphorylates a range of proteins, including histone H1 and tau.1 Cdk5 substrate is a synthetic peptide (PKTPKKAKKL) corresponding to a sequence of histone H1. It is phosphorylated by Cdk5 with a Km value of 5 µM.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Peterson, D.W., Ando, D.M., Taketa, D.A., et al. No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro. Proc. Natl. Acad. Sci. USA 107(7), 2884-2889 (2010).

    2. Beaudette, K.N., Lew, J., and Wang, J.H. Substrate specificity characterization of a cdc2-like protein kinase purified from bovine brain. The Journal of Biological Chemisty 268(28), 20825-20830 (1993).

    3. Sharma, P., Steinbach, P.J., Sharma, M., et al. Identification of substrate binding site of cyclin-dependent kinase 5. The Journal of Biological Chemisty 274(14), 9600-9606 (1999).