A cell-permeable peptide that blocks nuclear import of NF-κB
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NF-κB Inhibitor (trifluoroacetate salt)

Item No. 17493

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-alanyl-L-alanyl-L-valyl-L-alanyl-L-leucyl-L-leucyl-L-prolyl-L-alanyl-L-valyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-prolyl-L-valyl-L-glutaminyl-L-arginyl-L-lysyl-L-arginyl-L-glutaminyl-L-lysyl-L-leucyl-L-methionyl-L-proline, trifluoroacetate salt
Synonyms
  • SN50 Peptide
Molecular Formula
C129H230N36O29S • XCF3COOH
Formula Weight
2781.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
[H]N[C@H](C(N[C@H](C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N1CCC[C@H]1C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C(N2CCC[C@H]2C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@H](C(N3CCC[C@H]3C(O)=O)=O)CCSC)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)C)=O)=O)=O)=O)C)=O)=O)=O)=O)C)=O)=O)C)=O)C.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C129H230N36O29S.C2HF3O2/c1-64(2)57-87(156-117(183)92(62-69(11)12)158-123(189)100(72(17)18)161-106(172)78(25)143-119(185)94-41-35-54-164(94)126(192)93(63-70(13)14)159-118(184)90(60-67(7)8)154-104(170)76(23)144-121(187)99(71(15)16)160-105(171)77(24)141-102(168)74(21)132)113(179)142-75(22)103(169)153-89(59-66(5)6)116(182)157-88(58-65(3)4)114(180)145-79(26)124(190)163-53-34-42-95(163)120(186)162-101(73(19)20)122(188)151-85(45-47-98(134)167)112(178)149-82(39-32-51-139-128(135)136)108(174)146-80(37-28-30-49-130)107(173)148-83(40-33-52-140-129(137)138)109(175)150-84(44-46-97(133)166)111(177)147-81(38-29-31-50-131)110(176)155-91(61-68(9)10)115(181)152-86(48-56-195-27)125(191)165-55-36-43-96(165)127(193)194;3-2(4,5)1(6)7/h64-96,99-101H,28-63,130-132H2,1-27H3,(H2,133,166)(H2,134,167)(H,141,168)(H,142,179)(H,143,185)(H,144,187)(H,145,180)(H,146,174)(H,147,177)(H,148,173)(H,149,178)(H,150,175)(H,151,188)(H,152,181)(H,153,169)(H,154,170)(H,155,176)(H,156,183)(H,157,182)(H,158,189)(H,159,184)(H,160,171)(H,161,172)(H,162,186)(H,193,194)(H4,135,136,139)(H4,137,138,140);(H,6,7)/t74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,99-,100-,101-;/m0./s1
InChi Key
PNOSSAUHECMSIZ-RIIUDACNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    NF-κB inhibitor is a synthetic peptide corresponding to the nuclear localization sequence of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells.1 It blocks the nuclear import of p105 in cells treated with activators of NF-κB signaling, including LPS and TNF-α.1 In this way, NF-κB inhibitor blocks gene expression that is regulated by NF-κB.2,3 This peptide is commonly used to evaluate the role of NF-κB signaling in cellular responses.4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lin, Y.Z., Tao, S., Veach, R.A., et al. Inhibition of nuclear translocation of transcription factor NF-κB by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence. The Journal of Biological Chemisty 270(24), 14255-14258 (1995).

    2. Torgerson, T.R., Colosia, A.D., Donahue, J.P., et al. Regulation of NF-κB, AP-1, NFAT, and STAT1 nuclear import in T lymphocytes by noninvasive delivery of peptide carrying the nuclear localization sequence of NF-κB p50. J. Immunol. 161(11), 6084-6092 (1998).

    3. Kasibhatla, S., Genestier, L., and Green, D.R. Regulation of fas-ligand expression during activation-induced cell death in T lymphocytes via nuclear factor κB. The Journal of Biological Chemisty 274(2), 987-992 (1999).

    4. Methot, L., Hermann, R., Tang, Y., et al. Interaction and antagonistic roles of NF-κB and Hes6 in the regulation of cortical neurogenesis. Mol. Cell. Biol. 33(14), 2797-2808 (2013).

    5. Wäster, P., Rosdahl, I., and Ölinger, K. Cell fate regulated by nuclear factor-κB- and activator protein-1-dependent signalling in human melanocytes exposed to ultraviolet A and ultraviolet B. Br. J. Dermatol. 171(6), 1336-1346 (2014).

    Product Citations

    Yang, W., Yu, Z., Chiyoya, M., et al. Menaquinone-4 accelerates calcification of human aortic valve interstitial cells in high-phosphate medium through PXR. J. Pharm. Exp. Ther. 372, 277-284 (2020).