A natural agonist of Nur77
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Cytosporone B

Item No. 17501

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetic acid, ethyl ester
CAS Number
321661-62-5
Synonyms
  • Csn-B
  • Dothiorelone G
Molecular Formula
C18H26O5
Formula Weight
322.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
λmax
220, 270, 300 nm
SMILES
OC1=CC(CC(OCC)=O)=C(C(CCCCCCC)=O)C(O)=C1
InChi Code
InChI=1S/C18H26O5/c1-3-5-6-7-8-9-15(20)18-13(11-17(22)23-4-2)10-14(19)12-16(18)21/h10,12,19,21H,3-9,11H2,1-2H3
InChi Key
UVVWQQKSNZLUQA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $145

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    10 mg

    $268

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    25 mg

    $587

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    Product Description

    Cytosporone B is a naturally occurring agonist for the nuclear receptor Nur77 (IC50 = 0.278 nM).1 Activation of Nur77 with cytosporone B induces the expression of Nur77-dependent genes, including the gene for Nur77 itself.1 Signaling through Nur77 induces apoptosis in cancer cells and retards xenograft tumor growth.1 It also induces genes related to gluconeogenesis and decreases atherosclerosis progression in mice fed a high fat and high cholesterol diet.1,2 Cytosporone B is brain penetrant and aggravates early brain injury in rats when given (13 mg/kg intraperitoneally) after experimentally-induced subarachnoid hemorrhage.3 Cytosporone B also has antibacterial properties.4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhan, Y., Du, X., Chen, H., et al. Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nat. Chem. Biol. 4, 548-556 (2008).

    2. Hu, Y.W., Zhang, P., Yang, J.Y., et al. Nur77 decreases atherosclerosis progression in apoE-/- mice fed a high-fat/high-cholesterol diet. PLoS One 9(1), 1-12 (2014).

    3. Dai, Y., Zhang, W., Sun, Q., et al. Nuclear receptor nur77 promotes cerebral cell apoptosis and induces early brain injury after experimental subarachnoid hemorrhage in rats. J. Neurosci. Res. 92, 1110-1121 (2015).

    4. Beau, J., Mahid, N., Burda, W.N., et al. Epigenetic tailoring for the production of anti-infective cytosporones from the marine fungus Leucostoma persoonii. Mar. Drugs 10(4), 762-774 (2012).

    5. Li, J., Lv, C., Sun, W., et al. Cytosporone B, an inhibitor of the type III secretion system of Salmonella enterica serovar Typhimurium. Antimicrob. Agents Chemother. 57(5), 2191-2198 (2013).