An inhibitor of the PAF-AH1b2 and 1b3
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P11

Item No. 17507

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R,6R)-rel-2-[4-(1,1-dimethylethyl)phenyl]-1,2,5,6-tetrahydro-6-(4-methylphenyl)-1-[(4-methylphenyl)sulfonyl]-3-pyridinecarboxylic acid
CAS Number
942285-55-4
Molecular Formula
C30H33NO4S
Formula Weight
503.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
SMILES
OC(C1=CC[C@@H](C2=CC=C(C)C=C2)N(S(C3=CC=C(C)C=C3)(=O)=O)[C@H]1C4=CC=C(C(C)(C)C)C=C4)=O
InChi Code
InChI=1S/C30H33NO4S/c1-20-6-10-22(11-7-20)27-19-18-26(29(32)33)28(23-12-14-24(15-13-23)30(3,4)5)31(27)36(34,35)25-16-8-21(2)9-17-25/h6-18,27-28H,19H2,1-5H3,(H,32,33)/t27-,28-/m0/s1
InChi Key
KUBDPRSHRVANQQ-NSOVKSMOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $36

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    1 mg

    $63

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    5 mg

    $253

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    10 mg

    $436

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    Product Description

    P11 is an inhibitor of PAF-AH1b2- and 1b3-mediated hydrolysis of PAF to lyso-PAF (IC50s = 37 and 880 nM, respectively) without significant effect on other brain serine hydrolases.1 At 10 µM, it has been shown to impair Neuro2a and PC3 tumor cell survival.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chang, J.W., Zuhl, A.M., Speers, A.E., et al. Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival. ACS Chem. Biol. (2015).