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A-796260 Degradant

Item No. 17515

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • LTI-258 Degradant
Technical Information
Formal Name
3,3,4-trimethyl-1-(1-(2-morpholinoethyl)-1H-indol-3-yl)pent-4-en-1-one
CAS Number
1616469-10-3
Molecular Formula
C22H30N2O2
Formula Weight
354.5
Purity
≥95%
Formulation
A 10 mg/ml solution in methanol
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 10 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
212, 246, 303 nm
SMILES
O=C(CC(C)(C)C(C)=C)C1=CN(CCN2CCOCC2)C3=C1C=CC=C3
InChi Code
InChI=1S/C22H30N2O2/c1-17(2)22(3,4)15-21(25)19-16-24(20-8-6-5-7-18(19)20)10-9-23-11-13-26-14-12-23/h5-8,16H,1,9-15H2,2-4H3
InChi Key
LORODOQLOVWDSW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $129

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    Product Description

    A-796260 (Item No. 11606) is a synthetic cannabinoid (CB) that shows high selectivity for the CB2 receptor (Ki = 0.77 nM) over the CB1 receptor (Ki = 2,100 nM).1 It also shows efficacy in vivo in models of inflammatory, post-operative, neuropathic, and osteoarthritic pain, activities which are selectively blocked by CB2 receptor-selective antagonists.2 A-796260 degradant is an impurity that may be produced in the synthesis of A-796260. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Poso, A., and Huffman, J.W. Targeting the cannabinoid CB2 receptor: Modelling and structural determinants of CB2 selective ligands. Br. J. Pharmacol. 153(2), 335-346 (2008).

    2. Yao, B.B., Hsieh, G.C., Frost, J.M., et al. In vitro and in vivo characterization of A-796260: A selective cannabinoid CB2 receptor agonist exhibiting analgesic activity in rodent pain models. Br. J. Pharmacol. 153(2), 390-401 (2008).