A non-lipid agonist of LPA2
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

DBIBB

Item No. 17529

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[[4-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)butyl]amino]sulfonyl]-benzoic acid
CAS Number
1569309-92-7
Molecular Formula
C23H20N2O6S
Formula Weight
452.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
233, 333 nm
SMILES
O=C(C1=C2C(C=CC=C23)=CC=C1)N(CCCCNS(C4=C(C(O)=O)C=CC=C4)(=O)=O)C3=O
InChi Code
InChI=1S/C23H20N2O6S/c26-21-17-10-5-7-15-8-6-11-18(20(15)17)22(27)25(21)14-4-3-13-24-32(30,31)19-12-2-1-9-16(19)23(28)29/h1-2,5-12,24H,3-4,13-14H2,(H,28,29)
InChi Key
POLJNARIJSROOS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $63

    Add

    5 mg

    $242

    Add

    10 mg

    $333

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    The lysophosphatidic acid (LPA) receptor LPA2 is a G protein-coupled receptor that has roles in protecting against radiation-induced cell death.1 DBIBB is a non-lipid agonist of LPA2 (EC50 = 0.10 µM) that is without effect at other LPA receptor subtypes.2 It protects rat intestinal crypt epithelium-like IEC-6 cells against caspase 3/7 activation and apoptosis following irradiation.2 DBIBB dose-dependently attenuates radiation-induced DNA damage in mouse embryo fibroblasts (MEFs) expressing LPA2 but not in MEFs lacking this receptor.2 It also increases the survival of mice suffering from hematopoietic acute radiation syndrome after total-body irradiation.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lin, F.T., Lai, Y.J., Makarova, N., et al. The lysophosphatidic acid 2 receptor mediates down-regulation of Siva-1 to promote cell survival. The Journal of Biological Chemisty 282(52), 37759-37769 (2007).

    2. Patil, R., Szabó, E., Fells, J.I., et al. Combined mitigation of the gastrointestinal and hematopoietic acute radiation syndromes by an LPA2 receptor-specific nonlipid agonist. Chem. Biol. 22, 206-216 (2015).