An L-type calcium channel blocker
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Nitrendipine

Item No. 17549

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-ethyl 5-methyl ester
CAS Number
39562-70-4
Molecular Formula
C18H20N2O6
Formula Weight
360.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:4): 0.2 mg/mlDMSO: 25 mg/mlEthanol: 2 mg/ml
λmax
236, 353 nm
SMILES
CC1=C(C(C(C(OCC)=O)=C(N1)C)C2=CC([N+]([O-])=O)=CC=C2)C(OC)=O
InChi Code
InChI=1S/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)12-7-6-8-13(9-12)20(23)24/h6-9,16,19H,5H2,1-4H3
InChi Key
PVHUJELLJLJGLN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    10 mg

    $36

    Add

    50 mg

    $120

    Add

    100 mg

    $183

    Add

    500 mg

    $420

    Add
    Product Description

    Nitrendipine is a dihydropyridine used as an antihypertensive agent due to its ability to block L-type and T-type calcium channels, which play key roles in excitation-contraction coupling in cardiac and vascular smooth muscle cells, producing vasodilatory actions.1,2,3,4 It also binds to adenosine A1, A2A, and A3 receptors with Ki values of 8.96, 23.0, and 8.3 µM, respectively.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Furukawa, T., Yamakawa, T., Midera, T., et al. Selectivities of dihydropyridine derivatives in blocking Ca2+ channel subtypes expressed in Xenopus oocytes. J. Pharmacol. Exp. Ther. 291(2), 464-473 (1999).

    2. Triggle, D.J., and Rampe, D. 1,4-Dihydropyridine activators and antagonists: Structural and functional distinctions. Trends Pharmacol. Sci. 10(12), 507-511 (1989).

    3. Perez-Reyes, E., Van Deusen, A.L., and Vitko, I. Molecular pharmacology of human Cav3.2 T-type Ca2+ channels: Block by antihypertensives, antiarrhythmics, and their analogs. J. Pharmacol. Exp. Ther. 328(2), 621-627 (2009).

    4. Sonoda, S., and Ochi, R. Independent modulation of L-type Ca2+ channel in guinea pig ventricular cells by nitrendipine and isoproterenol. Jpn. Heart J. 42(6), 771-780 (2001).

    5. van Rhee, A.M., Jiang, J.L., Melman, N., et al. Interaction of 1,4-dihydropyridine and pyridine derivatives with adenosine receptors: Selectivity for A3 receptors. J. Med. Chem. 39(15), 2980-2989 (1996).