An internal standard for the quantification of minoxidil
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Unlabeled Version(s)
15302Minoxidil
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Minoxidil-d10

Item No. 17563

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(1-piperidinyl-d10)-2,4-pyrimidinediamine 3-oxide
CAS Number
1020718-66-4
Synonyms
  • Loniten-d10
  • U-10858-d10
Molecular Formula
C9H5D10N5O
Formula Weight
219.3
Purity
≥99% deuterated forms (d1-d10)
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 2 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): 2 mg/ml
λmax
230, 262, 284 nm
SMILES
NC1=[N+]([O-])C(N)=NC(N2C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C2([2H])[2H])=C1
InChi Code
InChI=1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6H,1-5,10H2,(H2,11,12)/i1D2,2D2,3D2,4D2,5D2
InChi Key
ZFMITUMMTDLWHR-YXALHFAPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    1 mg

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    5 mg

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    10 mg

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    Product Description

    Minoxidil-d10 is intended for use as an internal standard for the quantification of minoxidil (Item No. 15302) by GC- or LC-MS. Minoxidil is a pyrimidine derivative that was originally developed as an anti-hypertensive agent and unexpectedly found to stimulate hair growth. Minoxidil directly affects arteriolar smooth muscle to decrease vascular resistance in part by opening ATP-sensitive potassium channels.1,2 It can activate cyclooxygenase 1 (AC50 = 80 μM), which is expressed in the dermal papilla of hair follicles, increasing prostaglandin E2 production in BALB/c 3T3 fibroblasts and human dermal papilla fibroblasts.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Limas, C.J., and Cohn, J.N. Stimulation of vascular smooth muscle sodium, potassium--adenosinetriphosphatase by vasodilators. Circ. Res. 35(4), 601-607 (1974).

    2. Imenshahidi, M., Hadizadeh, F., Firoozeh-Moghadam, A., et al. Synthesis and vasorelaxant effect of 9-aryl-1,8-acridinediones as potassium channel openers in isolated rat aorta. Iran. J. Pharm. Res. 11(1), 229-233 (2012).

    3. Michelet, J.F., Commo, S., Billoni, N., et al. Activation of cytoprotective prostaglandin synthase-1 by minoxidil as a possible explanation for its hair growth-stimulating effect. J. Invest. Dermatol. 108, 205-209 (1997).