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Perindoprilat

Item № 17574
CAS № 95153-31-4
Purity ≥95%
product image
                (CAS 95153-31-4)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     500 µg $45.00 0.00
     1 mg $77.00 0.00
     5 mg $293.00 0.00

Pricing updated 2019-06-26. Prices are subject to change without notice.

Description
Synonyms
  • S-9780

Perindoprilat is the active metabolite of perindopril, an inhibitor of angiotensin converting enzyme (ACE) that has efficacy against hypertension.1 Perindoprilat specifically and competitively inhibits ACE in vitro with IC50 values ranging between 1.5 and 3.2 nM. Elimination of perindoprilat is decreased in the elderly and in patients with heart or renal failure.1,2,3

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Technical Information
Formal Name
(2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-carboxybutyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid
CAS Number
95153-31-4
Synonyms
  • S-9780
Molecular Formula
C17H28N2O5
Formula Weight
340.4
Purity
≥95%
Formulation
A crystalline solid
SMILES
[H][C@]12[C@](N(C([C@H](C)N[C@@H](CCC)C(O)=O)=O)[C@H](C(O)=O)C2)([H])CCCC1
InChI Code
InChI=1S/C17H28N2O5/c1-3-6-12(16(21)22)18-10(2)15(20)19-13-8-5-4-7-11(13)9-14(19)17(23)24/h10-14,18H,3-9H2,1-2H3,(H,21,22)(H,23,24)/t10-,11-,12-,13-,14-/m0/s1
InChI Key
ODAIHABQVKJNIY-PEDHHIEDSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Wang, J.g., Pimenta, E., and Chwallek, F. Comparative review of the blood pressure-lowering and cardiovascular benefits of telmisartan and perindopril Vascular Health and Risk Management 10, 189-200 (2014).

2. Sennesael, J., Ali, A., Sweny, P., et al. The pharmacokinetics of perindopril and its effects of serum angiotensin converting enzyme activity in hypertensive patients with chronic renal failure Br.J.Clin.Pharmac. 33, 93-99 (1992).

3. Parker, E., Aarons, L., Rowland, M., et al. The pharmacokinetics of perindoprilat in normal volunteers and patients: Influence of age and disease state European Journal of Pharmaceutical Sciences 26(1), 104-113 (2005).

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