Pricing updated 2019-06-26. Prices are subject to change without notice.
Perindoprilat is the active metabolite of perindopril, an inhibitor of angiotensin converting enzyme (ACE) that has efficacy against hypertension.1 Perindoprilat specifically and competitively inhibits ACE in vitro with IC50 values ranging between 1.5 and 3.2 nM. Elimination of perindoprilat is decreased in the elderly and in patients with heart or renal failure.1,2,3
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Wang, J.g., Pimenta, E., and Chwallek, F. Comparative review of the blood pressure-
2. Sennesael, J., Ali, A., Sweny, P., et al. The pharmacokinetics of perindopril and its effects of serum angiotensin converting enzyme activity in hypertensive patients with chronic renal failure Br.J.Clin.Pharmac. 33, 93-99 (1992).
3. Parker, E., Aarons, L., Rowland, M., et al. The pharmacokinetics of perindoprilat in normal volunteers and patients: Influence of age and disease state European Journal of Pharmaceutical Sciences 26(1), 104-113 (2005).