An ACE inhibitor and active metabolite of perindopril
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Pro-drug Form(s)
20796Perindopril
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Perindoprilat

Item No. 17574

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-carboxybutyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid
CAS Number
95153-31-4
Synonyms
  • S-9780
Molecular Formula
C17H28N2O5
Formula Weight
340.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
[H][C@]12[C@](N(C([C@H](C)N[C@@H](CCC)C(O)=O)=O)[C@H](C(O)=O)C2)([H])CCCC1
InChi Code
InChI=1S/C17H28N2O5/c1-3-6-12(16(21)22)18-10(2)15(20)19-13-8-5-4-7-11(13)9-14(19)17(23)24/h10-14,18H,3-9H2,1-2H3,(H,21,22)(H,23,24)/t10-,11-,12-,13-,14-/m0/s1
InChi Key
ODAIHABQVKJNIY-PEDHHIEDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    Product Description

    Perindoprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC50 = 1.05 nM) and an active metabolite of the ACE inhibitor prodrug perindopril (Item No. 20796).1 It reduces expression of the mRNA encoding VEGF in KB oral squamous cell carcinoma cells when used at concentrations of 1 and 2 µM.2 Perindoprilat, in combination with bradykinin, induces endothelium-dependent relaxation in isolated dog basilar and coronary arteries with 30% maximum induction (IC30) values of 0.46 and 1.15 µM, respectively.3 In vivo, perindoprilat (20 µg/kg) reverses or prevents restricted oxygen-induced decreases in mean blood pressure, renal blood flow, and renal vascular resistance, as well as increases in the urine flow rate in an acute hypoxemia-induced rabbit model of renal hypoperfusion.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ceconi, C., Francolini, G., Olivares, A., et al. Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE. Eur. J. Pharmacol. 577(1-3), 1-6 (2007).

    2. Yasumatsu, R., Nakashima, T., Masuda, M., et al. Effects of the angiotensin-I converting enzyme inhibitor perindopril on tumor growth and angiogenesis in head and neck squamous cell carcinoma cells. J. Cancer Res. Clin. Oncol. 130(10), 567-573 (2004).

    3. Kerth, P.A., and Vanhoutte, P.M. Effects of perindoprilat on endothelium-dependent relaxations and contractions in isolated blood vessels. Am. J. Hypertens. 4(3 Pt 2), 226S-234S (1991).

    4. Huet, R., Gouyon, J.-B., and Guignard, J.-P. Prevention of hypoxemia-induced renal dysfunction by perindoprilat in the rabbit. Life Sci. 61(22), 2157-2165 (1997).