A glutamine synthetase inhibitor
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Isomer(s)
41348SYM 2081
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L-α-Aminoadipic Acid

Item No. 17579

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2S-amino-hexanedioic acid
CAS Number
1118-90-7
Synonyms
  • (S)-2-Aminohexanedioic Acid
Molecular Formula
C6H11NO4
Formula Weight
161.2
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
1N HCl: 10 mg/mlPBS (pH 7.2): 0.5 mg/ml
SMILES
OC(CCC[C@H](N)C(O)=O)=O
InChi Code
InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/t4-/m0/s1
InChi Key
OYIFNHCXNCRBQI-BYPYZUCNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

    $36

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    500 mg

    $63

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    1 g

    $90

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    5 g

    $303

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    Product Description

    L-α-Aminoadipic acid is a gliotoxic analog of the excitatory neurotransmitter glutamate that competitively inhibits glutamine synthetase with a Ki value of 209 µM.1,2 It actively accumulates in glial cells and inhibits the glutamate transporter with a Ki value of 192 µM.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Huck, S., Grass, F., and Hörtnagl, H. The glutamate analogue α-aminoadipic acid is taken up by astrocytes before exerting its gliotoxic effect in vitro. J. Neurosci. 4(10), 2650-2657 (1984).

    2. McBean, G.J. Inhibition of the glutamate transporter and glial enzymes in rat striatum by the gliotoxin, αaminoadipate. Br. J. Pharmacol. 113(2), 536-540 (1994).