An agonist of dopamine D1A and D1B receptors
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Fenoldopam (mesylate)

Item No. 17629

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol, monomethanesulfonate
CAS Number
67227-57-0
Synonyms
  • SKF 82526J
Molecular Formula
C16H16ClNO3 • CH3SO3H
Formula Weight
401.9
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 1 mg/mlEthanol: 0.25 mg/ml
SMILES
OC(C=C1)=CC=C1C2CNCCC3=C2C=C(O)C(O)=C3Cl.CS(=O)(O)=O
InChi Code
InChI=1S/C16H16ClNO3.CH4O3S/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21;1-5(2,3)4/h1-4,7,13,18-21H,5-6,8H2;1H3,(H,2,3,4)
InChi Key
CVKUMNRCIJMVAR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    5 mg

    $53

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    10 mg

    $98

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    50 mg

    $231

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    100 mg

    $409

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    Product Description

    Fenoldopam is an agonist of dopamine D1A (D1R) and D1B (D5R) receptors (Kds = 17 and 11 nM, respectively).1,2 Fenoldopam is used to study the roles of these receptors, in cells and in vivo, and to alter hemodynamic properties, including hypertension, in animals.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Carey, R.M., Stote, R.M., Dubb, J.W., et al. Selective peripheral dopamine-1 receptor stimulation with fenoldopam in human essential hypertension. J. Clin. Invest. 74(6), 2198-2207 (1984).

    2. Tiberi, M., Jarvie, K.R., Silvia, C., et al. Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: Differential expression pattern in rat brain compared with the D1A receptor. Proc. Natl. Acad. Sci. USA 88(17), 7491-7495 (1991).

    3. Gildea, J.J., Shah, I.T., Van Sciver, R., et al. The cooperative roles of the dopamine receptors, D1R and D5R, on the regulation of renal sodium transport. Kidney Int. 86(1), 118-126 (2014).

    4. Swanson, T.A., Conte, T., Deeley, B., et al. Hemodynamic correlates of drug-induced vascular injury in the rat using high-frequency ultrasound imaging. Toxicol. Pathol. 42(4), 784-791 (2014).