A group IIA sPLA2 inhibitor
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YM-26734

Item No. 17631

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,1'-[5-[3,4-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl]-2,4,6-trihydroxy-1,3-phenylene]bis-1-dodecanone
CAS Number
144337-18-8
Molecular Formula
C45H62O8
Formula Weight
731.0
Purity
≥95% (mixture of diastereomers)
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 20 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:4): 0.2 mg/ml
λmax
276, 344 nm
SMILES
OC(C=C1)=CC2=C1C(C3=C(O)C(C(CCCCCCCCCCC)=O)=C(O)C(C(CCCCCCCCCCC)=O)=C3O)CC(C4=CC=C(O)C=C4)O2
InChi Code
InChI=1S/C45H62O8/c1-3-5-7-9-11-13-15-17-19-21-36(48)41-43(50)40(44(51)42(45(41)52)37(49)22-20-18-16-14-12-10-8-6-4-2)35-30-38(31-23-25-32(46)26-24-31)53-39-29-33(47)27-28-34(35)39/h23-29,35,38,46-47,50-52H,3-22,30H2,1-2H3
InChi Key
CEJAYJCUSZHYDS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    YM-26734 is a derivative of a compound isolated from the fruit of H. amygdaline that competitively inhibits rabbit platelet sPLA2 with an IC50 value of 85 nM.1 It inhibits sPLA2-hGIIA, -mGIIA, -rGIIA, -hGV, -mGV, -hGX, and -mGX with IC50 values of 80, 30, 120, 110, 520, >1600, and >1600 nM, respectively.2,3 YM-26734 displays minimal activity at cytosolic PLA2, COX and lipoxygenase.1 At 45 µg/ear or 11 mg/kg i.v., YM-26734 has been used to ameliorate local inflammatory responses in TPA-induced mouse ear edema.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Miyake, A., Yamamoto, H., Kubota, E., et al. Suppression of inflammatory responses to 12-O-tetradecanoyl-phorbol-13-acetate and carrageenin by YM-26734, a selective inhibitor of extracellular group II phospholipase A2. Br. J. Pharmacol. 110(1), 447-453 (1993).

    2. Oslund, R.C., Cermak, N., Verlinde, C.L.M.J., et al. Simplified YM-26734 inhibitors of secreted phospholipase A2 group IIA. Bioorg. Med. Chem. Lett. 18(20), 5415-5419 (2008).

    3. Lambeau, G., and Gelb, M.H. Biochemistry and physiology of mammalian secreted phospholipases A2. Annu. Rev. Biochem. 77, 495-520 (2008).