Dual inhibitor of PLD1 and PLD2
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ML-299

Item No. 17632

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-bromo-N-[(1S)-2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]-1-methylethyl]-benzamide
CAS Number
1426916-00-8
Synonyms
  • CID-56593087
Molecular Formula
C23H26BrFN4O2
Formula Weight
489.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:20): 0.5 mg/mlDMSO: 25 mg/mlEthanol: 1 mg/ml
λmax
247 nm
SMILES
BrC1=CC=C(C(N[C@@H](C)CN2CCC3(C(NCN3C4=CC(F)=CC=C4)=O)CC2)=O)C=C1
InChi Code
InChI=1S/C23H26BrFN4O2/c1-16(27-21(30)17-5-7-18(24)8-6-17)14-28-11-9-23(10-12-28)22(31)26-15-29(23)20-4-2-3-19(25)13-20/h2-8,13,16H,9-12,14-15H2,1H3,(H,26,31)(H,27,30)/t16-/m0/s1
InChi Key
RFKXAYJUFUZBMA-INIZCTEOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $63

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    1 mg

    $118

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    5 mg

    $481

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    Product Description

    ML-299 is a dual inhibitor of phospholipase D1 (PLD1) and PLD2 (IC50s = 6 and 20 nM, respectively).1 It is selective for PLD1 and PLD2 over a panel of 65 receptors but also inhibits human-ether-a-go-go (hERG), also known as Kv11.1, as well as κ- and µ-opioid receptors at 10 µM.2 ML-299 (1 and 10 µM) decreases invasive migration of U87MG glioblastoma cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. O'Reilly, M.C., Scott, S.A., Brown, K.A., et al. Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-triazaspiro[4.5]decane core: Discovery of ML298 and ML299 that decrease invasive migration in U87-MG glioblastoma cells. J. Med. Chem. 56(6), 2695-2699 (2013).

    2. Scott, S.A., O'Reilly, M.C., Daniels, J.S., et al. Development of a selective, allosteric PLD1/2 inhibitor in a novel scaffold. P01 ES013125, 1-4 (2013).