An inhibitor of Sec14
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SMI-481

Item No. 17637

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4-chloro-3-nitrophenyl)[4-(2-fluorophenyl)-1-piperazinyl]-methanone
CAS Number
432020-20-7
Molecular Formula
C17H15ClFN3O3
Formula Weight
363.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMF:PBS (pH 7.2) (1:4): 0.2 mg/mlDMSO: 30 mg/mlEthanol: 0.3 mg/ml
λmax
240 nm
SMILES
FC1=C(N2CCN(C(C3=CC([N+]([O-])=O)=C(Cl)C=C3)=O)CC2)C=CC=C1
InChi Code
InChI=1S/C17H15ClFN3O3/c18-13-6-5-12(11-16(13)22(24)25)17(23)21-9-7-20(8-10-21)15-4-2-1-3-14(15)19/h1-6,11H,7-10H2
InChi Key
LSPJXCGEFJDMHA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    25 mg

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    Product Description

    SMI-481 is an inhibitor of the yeast PITP Sec14, blocking both Sec14-mediated transfer of [3H]-PtdIns in vitro and growth (IC50s = 0.21 and 2.87 µM, respectively).1 Suppression of Sec14 expression leads to proportional reduction in SMI-481 inhibition, suggesting that SMI-481 acts specifically through Sec14.1 Moreover, SMI-481 does not affect [3H]-PtdIns transfer mediated by other yeast PITPs.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nile, A.H., Tripathi, A., Yuan, P., et al. PITPs as targets for selectively interfering with phosphoinositide signaling in cells. Nat. Chem. Biol. 10(1), 76-84 (2014).