A selective S1P2 receptor agonist
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CYM 5520

Item No. 17638

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[2-[2,5-dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethyl]-1,6-dihydro-6-oxo-3-pyridinecarbonitrile
CAS Number
1449747-00-5
Molecular Formula
C21H19N3O2
Formula Weight
345.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/ml
λmax
254, 301 nm
SMILES
O=C1C=CC(C#N)=CN1CC(C2=C(C)N(CC3=CC=CC=C3)C(C)=C2)=O
InChi Code
InChI=1S/C21H19N3O2/c1-15-10-19(16(2)24(15)13-17-6-4-3-5-7-17)20(25)14-23-12-18(11-22)8-9-21(23)26/h3-10,12H,13-14H2,1-2H3
InChi Key
FMYGNANMYYHBSU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $103

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    10 mg

    $183

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    Product Description

    Sphingosine-1-phosphate (S1P; Item No. 62570) is an extracellular lipid mediator whose major effects are mediated through five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. S1P2 has been implicated in multiple biological functions, including Rho activation, inhibition of Rac and cell migration, and in “feed forward” autocrine signaling in NF-κB survival signaling of tumor cells.1 CYM 5520 is a noncompetitive allosteric agonist of S1P2 (EC50 = 0.48 μM) that does not display agonist activity towards S1P1, S1P3, S1P4, or S1P5.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Satsu, H., Schaeffer, M.T., Guerrero, M., et al. A sphingosine 1-phosphate receptor 2 selective allosteric agonist. Bioorg. Med. Chem. 21(17), 5373-5382 (2013).