A synthetic agonist of GPR55
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ML-184

Item No. 17641

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[4-(2,3-dimethylphenyl)-1-piperazinyl]carbonyl]-N,N-dimethyl-4-(1-pyrrolidinyl)-benzenesulfonamide
CAS Number
794572-10-4
Synonyms
  • CID-2440433
Molecular Formula
C25H34N4O3S
Formula Weight
470.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:4): 0.2 mg/mlDMSO: 20 mg/mlEthanol: 1 mg/ml
λmax
210, 290 nm
SMILES
CC1=CC=CC(N2CCN(C(C3=CC(S(N(C)C)(=O)=O)=CC=C3N4CCCC4)=O)CC2)=C1C
InChi Code
InChI=1S/C25H34N4O3S/c1-19-8-7-9-23(20(19)2)28-14-16-29(17-15-28)25(30)22-18-21(33(31,32)26(3)4)10-11-24(22)27-12-5-6-13-27/h7-11,18H,5-6,12-17H2,1-4H3
InChi Key
VRSJAHQGJHDACS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $29

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    5 mg

    $99

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    10 mg

    $184

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    25 mg

    $387

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    Product Description

    GPR55 is a G protein-coupled receptor that is weakly activated by some cannabinoids (CBs) at nM concentrations but displays a 5- to 10-fold greater stimulation in response to 1 µM lysophosphatidylinositol (LPI).1,2 ML-184 is a potent synthetic agonist of GPR55 (EC50 = 0.26 µM).3 It does not act at the related kynurenic acid receptor GPR35 and is a weak antagonist of CB1 and CB2 (IC50s = 21.8 and 15.1 µM, respectively).3 Like LPI, ML-184 induces phosphorylation of ERK1/2 and translocation of PKCβII to the plasma membrane by activating GPR55.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ryberg, E., Larsson, N., Sjögren, S., et al. The orphan receptor GPR55 is a novel cannabinoid receptor. Br. J. Pharmacol. 152(7), 1092-1101 (2007).

    2. Oka, S., Nakajima, K., Yamashita, A., et al. Identification of GPR55 as a lysophosphatidylinositol receptor. Biochem. Biophys. Res. Commun. 362(4), 928-934 (2007).

    3. Kotsikorou, E., Madrigal, K.E., Hurst, D.P., et al. Identification of the GPR55 agonist binding site using a novel set of high potency GPR55 selective ligands. Biochemistry 50(25), 5633-5647 (2011).